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When considering antidepressants for sleep, Trazodone is often used due to its sedative properties. However, the best choice can vary depending on the individual's specific symptoms, medical history, and other medications they may be taking. It is important for the individual to consult with a healthcare provider to determine the most appropriate medication for their needs.

Imipramine carries a black box warning regarding an increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults when used for the treatment of major depressive disorder and other psychiatric disorders. It is important for healthcare providers to closely monitor patients of all ages for clinical worsening, suicidality, or unusual changes in behavior, especially during the initial few months of treatment or when the dose is adjusted.

Imipramine can be harmful if not used as prescribed because it may cause side effects such as dizziness, dry mouth, constipation, blurred vision, and weight gain. More serious risks include an increased chance of suicidal thoughts, especially in young adults, and potential heart-related issues like arrhythmias. It is important for individuals to use imipramine under the guidance of a healthcare provider to minimize these risks.

Imipramine is primarily used to treat major depressive disorder. It is also sometimes used to treat enuresis (bedwetting) in children.

Imipramine can cause drowsiness as a side effect, which may make a person feel sleepy. It is important for individuals taking imipramine to be aware of how it affects them, especially when performing tasks that require alertness, such as driving. If drowsiness becomes problematic, it is advisable to consult a healthcare provider.