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When considering estrogen therapy, either on its own or combined with another hormone like progestin, it’s important to be aware of potential serious side effects, though they are rare. It is crucial to discuss the potential risks and benefits of hormone treatment with your healthcare provider. Please note that estrogens are not recommended for preventing heart disease or dementia.

Key safety information includes:

• Cancer Risks: Estrogen use can increase the risk of uterine (endometrial) cancer. Following your doctor's advice on progestin use may help reduce this risk. Unusual vaginal bleeding should be reported to your doctor immediately.

• Postmenopausal Concerns: For women who are postmenopausal, estrogen therapy, with or without progestin, may elevate the risk of breast and ovarian cancer, stroke, dementia, and serious blood clots. When combined with progestin, there is also an increased risk of heart disease, including heart attacks.

• Dosage and Duration: The likelihood of serious side effects may be influenced by the estrogen dose and the duration of its use. It is recommended to use the lowest effective dose for the shortest period necessary. Regular consultations with your doctor are essential, ideally every 3 to 6 months, to evaluate the continued need for this medication.

• Long-term Use: If long-term use of this medication is necessary, ensure you have complete physical examinations at least annually, as advised by your healthcare provider.

Ensuring regular communication and check-ups with your healthcare provider is critical to managing the risks associated with estrogen therapy effectively.

When taking this medication, some common side effects may include nausea, vomiting, bloating, diarrhea, breast tenderness, headaches, and weight changes. These are generally mild, but if any persist or worsen, it's important to inform your healthcare provider. Most individuals using this medication do not experience serious side effects.

However, there are more severe side effects to be aware of. Mental or mood changes, such as new or worsening depression, lumps in the breast, and unusual changes in vaginal bleeding should be reported to a healthcare professional immediately. Additionally, increased or new vaginal irritation, itching, odor, or discharge, as well as signs of liver problems like persistent nausea, loss of appetite, stomach pain, jaundice, and dark urine, are serious and require prompt medical attention. Swelling of the hands, ankles, or feet and symptoms of high blood sugar, such as increased thirst and urination, should also be monitored closely.

Rarely, this medication may lead to serious and potentially fatal blood clot issues, including heart attack, stroke, or clots in the lungs or legs. Seek urgent medical help if you experience symptoms like shortness of breath, chest pain, unusual sweating, confusion, sudden dizziness, pain or swelling in the groin or calf, severe headaches, difficulty speaking, weakness on one side of the body, or sudden vision changes.

Though a very serious allergic reaction is rare, it can occur. Immediate medical assistance is necessary if symptoms such as rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or trouble breathing appear. This summary does not include all possible side effects, so it's crucial to consult a healthcare provider if other unexpected symptoms occur.