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Leucovorin itself is not typically associated with hair loss. It is often used to reduce the side effects of certain chemotherapy drugs, which can cause hair loss. If hair loss occurs, it is more likely due to the chemotherapy rather than leucovorin.

Leucovorin is used in chemotherapy protocols primarily to enhance the effectiveness of certain drugs or to reduce their toxic side effects. When used with methotrexate, leucovorin acts as a "rescue" agent to protect healthy cells from the drug's toxicity. In combination with 5-fluorouracil (5-FU), leucovorin enhances the drug's effectiveness against cancer cells.

Leucovorin is given with certain chemotherapy drugs, such as methotrexate, to help protect healthy cells from the toxic effects of the chemotherapy. It acts as a "rescue" agent by providing a source of folinic acid, which helps to reduce the side effects and toxicity associated with these treatments. Additionally, leucovorin can enhance the effectiveness of other chemotherapy drugs, like 5-fluorouracil, by stabilizing the bond between the drug and its target enzyme, thereby increasing its anticancer activity.

Folic acid and folinic acid are both forms of vitamin B9, but they differ in their chemical structure and biological activity. Folic acid is a synthetic form of vitamin B9, commonly used in supplements and fortified foods. It requires conversion in the body to become active. Folinic acid, also known as leucovorin, is a naturally occurring form that is already in an active state, bypassing the need for conversion. This makes folinic acid more readily usable by the body, especially in individuals with certain metabolic disorders.

Folic acid should not be taken with methotrexate because it can interfere with the drug's effectiveness. Methotrexate works by inhibiting the metabolism of folic acid, which is necessary for the drug to exert its therapeutic effects, particularly in conditions like cancer and autoimmune diseases. Taking folic acid supplements can counteract this mechanism, potentially reducing methotrexate's efficacy. However, in some cases, healthcare providers may prescribe folic acid to mitigate side effects of methotrexate, such as folate deficiency, but this should be done under medical supervision.