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The use of Myrbetriq (mirabegron) requires careful consideration of certain safety warnings and potential risks. It is important to be aware of these aspects and discuss any concerns with your healthcare provider.

• High Blood Pressure: Myrbetriq (mirabegron) may increase blood pressure. It is not recommended for individuals with severe, uncontrolled high blood pressure. Regular monitoring of blood pressure is advised. In the event of symptoms such as headaches, chest pain, or visual changes, seek medical attention immediately, as these may indicate critically high blood pressure levels.

• Difficulty Emptying the Bladder: If you have a bladder obstruction or are using specific medications for overactive bladder, consult your healthcare provider before starting Myrbetriq (mirabegron). There is a risk of incomplete bladder emptying, although no cases have been documented. Inability to fully empty the bladder could lead to complications like bladder damage or infections. Report to your provider if you experience fullness without the ability to urinate.

• Angioedema (Unusual Swelling): Rarely, Myrbetriq (mirabegron) can cause angioedema, an allergic reaction resulting in swelling of the face, lips, or throat, potentially causing breathing difficulties. This may occur shortly after the initial dose or after multiple doses. Immediate medical assistance is crucial if breathing becomes difficult or throat swelling occurs.

• Medication Interactions: Myrbetriq (mirabegron) can alter the effects of other drugs, such as digoxin (Lanoxin) and warfarin (Coumadin), increasing their concentration and the risk of side effects. Your doctor may need to adjust dosages and monitor your health closely. Ensure your healthcare provider is informed about all medications, including prescription, over-the-counter drugs, vitamins, and supplements, prior to starting Myrbetriq (mirabegron).

Please consult your healthcare professional for personalized advice and any additional questions regarding the use of Myrbetriq (mirabegron).

Common side effects:

• nausea
• dizziness
• headaches
• symptoms resembling a common cold
• runny or stuffy nose
• high blood pressure

Less common but important to monitor:

• constipation
• urinary tract infections

Serious side effects:

• fast heart rate
• joint pain
• diarrhea
• stomach pain
• severe fatigue
• burning or painful urination
• allergic reaction
• rash
• severe dizziness
• itching or swelling
• trouble breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Eliglustat
• Thioridazine

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Clozapine
• Codeine
• Dihydrocodeine
• Propafenone
• Sirolimus
• Tramadol

Interactions with low risk that usually do not require a change in therapy:

• Desipramine
• Digoxin
• Metoprolol