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This medication has caused an increase in a type of bone cancer (osteosarcoma) in rats. It is unknown if it will increase the chance of bone cancer in humans. Before using this medication, tell your doctor or pharmacist your medical history, especially of Paget's disease or other bone disease, increase in a certain enzyme in your blood (alkaline phosphatase), personal/family history of bone cancer, or radiation treatment. Talk with your doctor about the benefits and risks of using this medication. This medication should not be used by children and young adults whose bones are still growing, since they might have an increased risk of bone cancer. To receive parathyroid hormone in the United States, you must understand, agree to, and carefully follow the requirements of the REMS Program for this medication. If you live in Canada or any other country, consult your doctor and pharmacist for your country's regulations.

Skin tingling, tickling, or a burning feeling may occur. Nausea, vomiting, or diarrhea may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. High blood calcium can occur, especially when you first start using this medication. Tell your doctor right away if you have symptoms such as constipation, abdominal pain, unusual thirst, frequent urination, or muscle weakness. Low blood calcium can also occur, especially if you stop using or miss a dose of this medication. Tell your doctor right away if you develop symptoms of low blood calcium, such as tingling of your lips/tongue/fingers/feet, twitching of face muscles, cramps in your feet/hands, seizures, depression, or having problems thinking or remembering. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.