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When using this medication, you might experience mild itching, redness, burning, or stinging where it is applied. If the redness persists beyond four days, discontinue use and consult a healthcare professional. Other possible side effects include nausea, dizziness, flushing, heartburn, and headaches. It's also common to encounter nicotine withdrawal symptoms, such as dizziness, anxiety, depression, or sleep disturbances when you stop smoking. Should these symptoms persist or worsen, seek advice from a healthcare provider.

Serious side effects, though less common, may occur if you continue smoking while using the medication. These include mood changes like irritability or vivid dreams, numbness or tingling in the extremities, and swelling in the hands or feet. It is crucial to stop using the medication and consult a healthcare professional immediately if these symptoms develop.

In the event of very serious side effects such as chest pain, confusion, severe headache, irregular heartbeat, difficulty speaking, or unilateral weakness, seek emergency medical assistance. While a severe allergic reaction is rare, watch for signs such as rash, swelling (particularly of the face, tongue, or throat), severe dizziness, or breathing difficulties, and obtain medical help right away. This overview does not cover all possible side effects; consult a healthcare provider if you notice other unusual symptoms.