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This medication comes with important safety information that you should carefully consider. It is crucial to discuss any concerns with your healthcare provider.

• Enlarged Spleen: Rare cases of spleen enlargement have been reported with Neupogen (filgrastim) use. In severe instances, the spleen may rupture, which is potentially fatal. Seek medical advice if you experience pain in the upper left abdomen or shoulder area.

• Respiratory Issues: Neupogen (filgrastim) may lead to acute respiratory distress syndrome (ARDS), a serious condition where fluid leaks into the lungs, diminishing oxygen supply to the blood and organs. Immediate medical attention is necessary if you experience shortness of breath, rapid breathing, or fever.

• Severe Allergic Reactions: Life-threatening allergic reactions can occur with Neupogen (filgrastim). Do not use this medication if you've previously had an allergic reaction to it or similar medications like Neulasta (pegfilgrastim). Always provide your healthcare team with an updated list of your allergies. Seek emergency help if you notice a rash, difficulty breathing, or swelling of the lips, tongue, or throat.

• Sickle Cell Crisis: Individuals with sickle cell anemia may experience a painful crisis when using Neupogen (filgrastim). If this occurs, your healthcare provider will discontinue the medication.

• Kidney Damage: Neupogen (filgrastim) may cause kidney damage. If kidney issues are suspected, your provider may order blood tests to monitor your condition, and they may adjust your dose or temporarily stop the medication if necessary.

• Capillary Leak Syndrome: This medication can cause capillary leak syndrome (CLS), where fluid escapes from small blood vessels. Symptoms include low blood pressure, fatigue, abdominal pain, extreme thirst, or sudden weight gain. Contact your provider if you experience these symptoms for further evaluation.

• Blood Vessel Damage: Filgrastim products have been linked to cutaneous vasculitis, a condition involving inflammation and tissue damage to blood vessels. Symptoms include itchy, red spots or bumps, general malaise, or muscle and joint pain. Consult your provider if these occur, as they may need to pause your treatment.

• Cancer Risk: As a growth factor, Neupogen (filgrastim) may promote tumor growth. Some users have developed blood-related cancers when using the medication for severe chronic neutropenia or in conjunction with chemotherapy or radiation for breast or lung cancer. Regular lab tests will be conducted to evaluate the continued use of Neupogen (filgrastim).

Contraindications: Do not use this medication if you have an allergy to pegfilgrastim products such as Neulasta. Consult your healthcare provider if you are unsure whether this applies to you.

When taking this medication, some common side effects may occur, though they are usually mild. These include dizziness, headache, and bone, joint, or muscle pain, which can often be alleviated with a non-aspirin pain reliever like acetaminophen. Additionally, you might experience redness, swelling, itching, or bruising at the injection site. If these effects persist or worsen, consult your healthcare provider. Other common side effects reported include fever, nausea, low platelet count, feeling weak or tired, cough, rash, shortness of breath, and chest pain.

While many individuals do not experience serious side effects, it's important to be aware of them. Serious side effects requiring immediate medical attention include easy bleeding or bruising, pink or bloody urine, bloody vomit, a fast heartbeat, fever, purple or red spots on the skin, and back pain. More severe reactions, though rare, such as breathing difficulties, unusual tiredness, or swelling of the body, demand urgent medical attention.

In very rare cases, this medication may lead to serious conditions, such as spleen damage, indicated by stomach or shoulder pain, or increase the risk of bone marrow disorders or blood cancer in specific populations. Additionally, a serious allergic reaction, while rare, may occur, characterized by a rash, itching or swelling of the face, tongue, or throat, severe dizziness, or difficulty breathing. If you experience any of these symptoms, seek immediate medical help. Always contact your healthcare provider if you notice any other unusual effects.

When using Neupogen (filgrastim), it is important to avoid taking pegfilgrastim at the same time, as both medications are very similar and should not be used together. Filgrastim can affect certain laboratory tests, such as bone imaging, potentially leading to inaccurate results. Therefore, it's crucial to inform all your healthcare providers and lab technicians about your use of filgrastim.

Additionally, Neupogen (filgrastim) might interact with certain medications or supplements. You should always inform your doctor and pharmacist about all other medications, including over-the-counter drugs, vitamins, and herbal supplements you are taking. Notably, drugs like Vincristine and Vincristine Sulfate Liposome are usually not recommended to be used with filgrastim, unless absolutely necessary. If your doctor prescribes these medications together, they may adjust the dosage or frequency to ensure safe use.