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This safety and warning information outlines important considerations for patients and healthcare professionals when using Omnipaque (iohexol). It is crucial to understand the potential risks and necessary precautions associated with this medication. Here are the key points to be aware of:

• Administration by Professionals: Omnipaque (iohexol) must only be administered by trained healthcare providers. Different strengths and formulations exist and are not interchangeable. Your healthcare provider will ensure you receive the correct formulation for your procedure.

• Serious Allergic Reactions: There is a risk of severe allergic reactions, including life-threatening anaphylaxis. Symptoms may include dizziness, nausea, a choking sensation, difficulty breathing, or swelling around the eyes, lips, or tongue. Seek immediate medical attention if these occur. Pre-medication with antihistamines or corticosteroids may be provided if you have a history of allergic reactions to contrast agents.

• Severe Skin Reactions: Omnipaque (iohexol) can cause serious skin reactions like Stevens-Johnson syndrome or toxic epidermal necrolysis, occurring from an hour to several weeks after administration. Report symptoms such as fever, body aches, and a painful rash to your provider immediately.

• Kidney Concerns: The use of Omnipaque (iohexol) can lead to severe kidney problems, especially in those over 65, with diabetes, pre-existing kidney issues, or taking medications that affect kidney function. Monitoring may be required before and after administration.

• Hypotension and Shock: The medication can cause sudden drops in blood pressure and shock, particularly in individuals with heart failure. Blood pressure will be monitored closely post-administration.

• Cardiac and Stroke Risk: Rarely, use during heart imaging may increase the risk of blood clots, potentially leading to heart attacks or strokes. Be vigilant for breathing difficulties, sudden chest pain, or weakness in the limbs.

• Hyperthyroidism and Thyroid Storm: Omnipaque (iohexol) may exacerbate hyperthyroidism and lead to thyroid storm. Inform your provider about any thyroid issues or medications like levothyroxine.

• Hypothyroidism in Children: In children aged 0 to 3, the medication may cause hypothyroidism, affecting brain development. Thyroid health will be monitored, and treatment provided if necessary.

• High Blood Pressure in Pheochromocytoma: Individuals with pheochromocytoma or paragangliomas may experience hypertensive crises. Blood pressure monitoring is essential after administration.

• Sickle Cell Crisis: For those with sickle cell disease, Omnipaque (iohexol) may trigger a sickle cell crisis. Adequate hydration will be ensured before and after administration.

• Contraindications: Certain conditions make the use of Omnipaque (iohexol) unsuitable, such as injecting specific formulations into the spine or using oral solutions for injection. Pregnant individuals, those with recent cervical surgeries, or signs of genital infection should avoid specific applications.

Always consult your healthcare provider if you have any concerns or conditions mentioned above. In case of an overdose, seek immediate medical assistance.

When taking this medication, some individuals may experience mild side effects such as diarrhea, nausea, vomiting, stomach pain, gas, or headaches. These symptoms are generally not a cause for concern and may resolve on their own. However, if they persist or worsen, it is advisable to consult your healthcare provider.

In some cases, people may report experiencing pain in areas such as the back, neck, or stiffness, which occurs in about 8% of users. Headaches are noted in 18% of adults and 9% of children taking the medication, while vomiting affects 3% of adults and 6% of children. These side effects are typically manageable but should be monitored.

Serious side effects are rare but warrant immediate medical attention. These include signs of kidney issues, such as a noticeable change in urine output. Additionally, a severe allergic reaction, although uncommon, may manifest as a rash, itching, swelling, severe dizziness, or difficulty breathing. Immediate medical help should be sought if any of these symptoms occur.

Remember, while these side effects are possible, many individuals do not experience significant issues with this medication. Always communicate with your healthcare provider about any side effects you encounter to ensure prompt and appropriate care.