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Yes, there can be downsides to taking digestive enzymes. Some individuals may experience side effects such as abdominal pain, diarrhea, nausea, or allergic reactions. Additionally, over-reliance on digestive enzymes might lead to the body producing fewer natural enzymes. It's important for individuals to consult with a healthcare provider before starting digestive enzymes to ensure they are appropriate for their specific health needs.

Individuals who should avoid taking papaya enzymes include those with allergies to papaya or latex, as there may be cross-reactivity. Pregnant or breastfeeding women should consult a healthcare provider before use. Additionally, people with certain medical conditions or those taking specific medications should seek medical advice to ensure safety.

Digestive enzymes can cause side effects in some individuals. Common side effects may include nausea, diarrhea, abdominal pain, and cramping. Some people might also experience allergic reactions, such as rash or itching. It's important to consult a healthcare provider if any adverse effects occur or if there are concerns about taking digestive enzymes.