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This medication includes both nirmatrelvir and ritonavir tablets. It is important to be aware that ritonavir can interact with a wide range of other medications, potentially leading to severe or even life-threatening reactions. Here are some crucial points to consider:

• Inform Your Healthcare Providers: Before starting treatment with nirmatrelvir and ritonavir, ensure that your doctor and pharmacist are informed about all the medications you are currently taking. This includes prescription medications, over-the-counter drugs, and herbal supplements.

• Check for Interactions: Before beginning any new medication or supplement, consult with your doctor or pharmacist to determine if it may interact adversely with nirmatrelvir and ritonavir.

• Avoid Certain Medications: Some medications should not be used in combination with this treatment. Always seek guidance from your healthcare provider to understand which drugs should be avoided.

• Drug Interaction Information: For further details on specific drug interactions, refer to the Drug Interactions section provided with your medication.

By following these precautions, you can help ensure the safe and effective use of nirmatrelvir and ritonavir.

While taking this medication, you might experience changes in taste or diarrhea. These side effects are usually mild, but if they persist or worsen, it's important to contact your healthcare provider. Most people using this medication do not encounter severe side effects.

However, be vigilant for any serious symptoms that could indicate liver problems, such as persistent nausea, vomiting, loss of appetite, stomach or abdominal pain, yellowing of the eyes or skin, or dark urine. These require immediate medical attention.

Though rare, a serious allergic reaction can occur. Seek urgent medical help if you experience symptoms like a rash, itching or swelling (particularly of the face, tongue, or throat), severe dizziness, or difficulty breathing. If you notice any other unusual effects, consult your healthcare provider promptly.

Some drugs can interact with nirmatrelvir/ritonavir, potentially altering how they or this medication work. For instance, Orlistat may interact with nirmatrelvir/ritonavir. This combination can either slow down or speed up the elimination of other drugs from your body, affecting their effectiveness. Medicines that may be affected include:

• Alfuzosin
• Certain heart rhythm medications like Amiodarone, Flecainide, Propafenone, and quinidine
• Azole antifungals such as Voriconazole
• Some benzodiazepines, including Midazolam and Triazolam
• Blood thinners like Rivaroxaban and Warfarin
• Eletriptan
• Treatments for erectile dysfunction or pulmonary hypertension, such as Avanafil and Sildenafil
• Ergot alkaloids including Dihydroergotamine, ergonovine, ergotamine, and Methylergonovine
• Lurasidone
• Certain opioids like Fentanyl and Meperidine
• Pimozide
• Ranolazine
• Salmeterol
• Certain statins such as Simvastatin and Lovastatin

Other medications may influence the removal of nirmatrelvir/ritonavir from your body, impacting its effectiveness. These include:

• Apalutamide
• Butalbital
• Encorafenib
• Enzalutamide
• Lumacaftor
• Mitotane
• Rifamycins like Rifampin and rifapentine
• St. John's wort
• Seizure medications such as Carbamazepine, Phenobarbital, and Phenytoin

Additionally, nirmatrelvir/ritonavir can decrease the effectiveness of hormonal contraceptives containing Ethinyl Estradiol, like pills, patches, or rings, potentially leading to pregnancy. It is important to discuss with your doctor or pharmacist whether you need an additional reliable birth control method while using this medication. Also, report any unexpected spotting or breakthrough bleeding to your doctor, as these may indicate that your birth control is less effective.