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Here is a professional summary of the safety and warning information for the medication, with critical details included:

Pravastatin is a medication that comes with several important safety warnings. It is crucial to be aware of these potential risks and consult your healthcare provider with any questions or concerns.

• Severe Muscle Pain and Damage: Pravastatin can lead to rhabdomyolysis, a serious and potentially life-threatening condition characterized by muscle damage that can harm the kidneys. Individuals over 65, those on higher doses, or those with kidney issues, uncontrolled hypothyroidism, or taking other interacting medications are at greater risk. Signs of rhabdomyolysis include severe muscle pain, tenderness, weakness, dark urine, fatigue, and should prompt immediate medical attention.

• Liver Problems: Pravastatin may cause severe liver issues, including liver failure, though these are rare. Regular liver function tests may be necessary before and during treatment. Symptoms such as abdominal swelling, pain, jaundice, changes in stool color, nausea, vomiting, or dark urine require urgent medical evaluation.

• Increased Blood Sugar Levels: Statins like pravastatin can elevate blood sugar levels, potentially affecting hemoglobin A1C. This is particularly relevant for individuals with diabetes or high blood sugar. Regular monitoring of blood sugar, alongside a healthy diet and exercise, is advised.

• Risks During Pregnancy and Breastfeeding: Pravastatin is generally not recommended during pregnancy or breastfeeding due to the potential risk to the fetus or infant. Discuss alternative options with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.

Contraindications:

• Individuals with liver conditions, such as liver failure or severe cirrhosis, should not use pravastatin. Always consult your healthcare provider if you have these conditions before starting the medication.

Common side effects:

• muscle, joint, or bone pain
• upper respiratory infections
• chest pain
• nausea
• vomiting
• tiredness
• headaches
• dizziness
• cough
• muscle cramps
• diarrhea

• rash

  Less common but important to monitor:

• mild memory problems
• confusion
• affect blood sugar levels

• potentially causing or worsening diabetes

  Serious side effects:

• severe muscle damage (rhabdomyolysis)
• liver problems
• severe allergic reaction

Interactions with high risk of serious adverse effects and should be avoided:

• Red Yeast Rice Products

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Colchicine
• Daptomycin
• Gemfibrozil
• Atazanavir
• Bempedoic Acid
• Cyclosporine

Interactions with low risk that usually do not require a change in therapy:

• Amprenavir
• Clarithromycin