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Propylthiouracil is a medication that comes with several important safety warnings and precautions. It is crucial to understand these potential risks and discuss them with your healthcare provider to ensure safe use of the drug. Here are the key points to consider:

• Liver Damage: There is a rare but serious risk of liver injury associated with propylthiouracil, especially within the first six months of treatment. Regular blood tests are recommended to monitor liver health. Contact your healthcare provider immediately if you experience nausea or vomiting that persists, severe stomach or abdominal pain, dark urine, or yellowing of the eyes or skin. Individuals with a history of liver problems should be particularly cautious.

• Risks During Pregnancy: Propylthiouracil should only be used during the first trimester of pregnancy if absolutely necessary due to its potential to cause severe liver damage in the mother. Pregnant individuals or those planning to become pregnant should consult their healthcare provider to determine if this medication is appropriate.

• Immune System Suppression: On rare occasions, propylthiouracil can decrease white blood cell counts, leading to a weakened immune system. This may increase the risk of infections, particularly if you are also taking other medications that suppress the immune system. Seek medical advice promptly if you develop a fever or sore throat while on this medication.

• Hypothyroidism Risk: Propylthiouracil can sometimes lower thyroid hormone levels excessively, resulting in hypothyroidism. Regular monitoring through blood tests is necessary to keep hormone levels within a normal range. If you are pregnant, it is crucial to maintain the correct dosage, as excessive amounts can affect fetal growth.

• Blood Vessel Inflammation: Rarely, this medication may cause vasculitis, an inflammation of the blood vessels, which can impact various organs such as the kidneys, lungs, brain, and colon. Notify your healthcare provider immediately if you have difficulty urinating, experience lower back pain, abdominal swelling and pain, fever, or notice blood in your urine or stool. This risk is heightened for those with a history of kidney problems.

In case of a suspected overdose, seek emergency medical assistance immediately. Always follow your healthcare provider's instructions and inform them of any other medications you are taking to avoid potential interactions.

Common side effects:

• nausea
• vomiting
• stomach upset
• mild rash or itching
• headache
• tingling sensations
• joint or muscle pain
• dizziness
• loss or change in taste
• swelling

Less common but important to monitor:

• skin rash
• skin discoloration
• vertigo
• yellowing of the eyes

Serious side effects:

• signs of low blood cell counts (fever, chills, cough, muscle aches)
• symptoms of potential liver damage (stomach pain, clay-colored stools, yellowing of the skin or eyes)
• signs of bleeding
• severe skin reactions (blisters or peeling)

Interactions with high risk of serious adverse effects and should be avoided:

• Macimorelin
• Pexidartinib

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Acenocoumarol
• Anisindione
• Dicumarol
• Phenindione
• Phenprocoumon
• Warfarin