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Lenalidomide, known as Revlimid, is a medication with significant safety considerations due to its potential risks. Below are key safety and warning points that should be carefully reviewed:

• Pregnancy Risks: Lenalidomide is highly teratogenic and can cause severe birth defects or death to an unborn baby. Women of childbearing potential must use two forms of effective contraception for at least four weeks before, during, and for four weeks after treatment. Regular pregnancy tests are mandatory before starting and throughout the treatment period. If pregnancy occurs, discontinue the drug immediately and contact your healthcare provider.

• REMS Program Compliance: In the US, lenalidomide is only available through the REMS program due to its risks. This program ensures that patients, prescribers, and pharmacies adhere to strict guidelines to prevent fetal exposure. If you are in another country, consult local regulations with your healthcare provider.

• Blood Clot Risk: Lenalidomide may increase the risk of blood clots, especially in patients with a history of clots, high cholesterol, hypertension, or those who smoke. The risk is also elevated when used with estrogen-containing products or dexamethasone. Inform your doctor if you have any risk factors, and seek immediate medical attention if you experience symptoms such as chest pain, shortness of breath, or leg swelling.

• Blood Cell Count Monitoring: This medication can cause a significant decrease in white and red blood cells, and platelets, increasing the risk of infections, anemia, and bleeding. Regular blood tests are necessary to monitor your cell counts, and your doctor may adjust your dosage accordingly.

• Potential for New Cancers: There is a rare risk of developing secondary cancers, such as blood or skin cancers, while taking lenalidomide. Discuss this risk with your healthcare provider.

• Liver Damage: Patients with liver issues or those taking other liver-impacting medications should use lenalidomide cautiously. Regular monitoring of liver function tests is advisable.

• Severe Skin Reactions: Lenalidomide may cause life-threatening skin reactions, such as Stevens-Johnson syndrome. Discontinue use and seek immediate medical help if you develop fever, blisters, or peeling skin.

• Tumor Lysis Syndrome: This rare but serious condition may occur when cancer cells break down rapidly, leading to high levels of uric acid and electrolytes. This can cause kidney damage and heart problems. Monitoring and preventive measures are recommended for those at risk.

• Tumor Flare Reaction: Some patients may experience a worsening of their tumor, known as a tumor flare reaction. Inform your doctor if you experience symptoms such as swollen lymph nodes, fever, or rash.

• Impaired Stem Cell Mobilization: Lenalidomide can affect stem cell collection for transplantation. Patients eligible for autologous stem cell transplantation should plan collection early in their treatment.

• Risk of Death in MCL: In clinical trials for mantle cell lymphoma (MCL), early deaths were more common in patients treated with lenalidomide than those given a placebo. Discuss the potential risks with your healthcare provider if you have MCL.

Consult your healthcare provider before starting lenalidomide, especially if any of these warnings apply to you. In case of an overdose, seek immediate medical assistance.

When taking this medication, some common side effects may occur, but they are generally mild. These include diarrhea, a decrease in red blood cells, neutrophils, and platelets, fatigue, back pain, muscle weakness, difficulty sleeping, rash, cough, reduced appetite, shortness of breath, fever, stomach pain, and muscle spasms. If these effects persist or worsen, it is advisable to contact your healthcare provider for guidance.

In addition to the common side effects, some individuals may experience heartburn, joint and muscle pain, pain in the limbs, respiratory infection symptoms, urinary tract infection symptoms like painful urination, headaches, itchy skin, and mood changes such as depression. If you experience these side effects, especially if they become severe, consult your healthcare professional.

There are also rare but serious side effects that require immediate medical attention. These include liver problems characterized by fatigue, loss of appetite, nausea, dark urine, and yellowing of the skin or eyes. Blood clots can also occur, presenting symptoms like weakness, numbness, trouble speaking, dizziness, chest pain, or difficulty breathing. Other severe reactions include serious skin issues like painful blisters or sores, tumor lysis syndrome, and serious infections or bleeding issues. If any of these severe side effects occur, seek urgent medical care.