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When using ustekinumab, some common side effects may include bruising, itching, pain, redness, swelling, or hardening of the skin at the injection site. These reactions are typically mild and tend to resolve within a day or two. Other less concerning side effects can consist of headache, back pain, and sinus or throat pain. If these symptoms persist or worsen, it is advisable to consult with a healthcare professional.

However, there are more serious side effects that require immediate medical attention. This medication can impair the immune system, increasing the likelihood of serious infections, such as those affecting the lungs, bones, joints, skin, sinuses, or bowel. Signs of infection include persistent nausea or vomiting, increased redness or swelling at the injection site after two days, fever, chills, cold or flu symptoms, painful or frequent urination, and unusual vaginal discharge.

A rare but severe condition associated with ustekinumab is posterior reversible encephalopathy syndrome (PRES). Symptoms to watch for include persistent headaches, seizures, sudden vision changes, and mental or mood changes like confusion. There is also a rare risk of developing certain types of cancer, including skin cancer. Be alert for unusual lumps, skin changes, or unexplained weight loss.

In rare cases, individuals may experience a serious allergic reaction, signaled by rash, itching or swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing. Immediate medical assistance is crucial if these symptoms arise. While this summary covers many potential side effects, it is not exhaustive. Always consult a healthcare provider for any concerns or unlisted symptoms.