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When taking this medication, it is important to be aware of potential interactions and precautions to ensure your safety and maximize the drug's effectiveness. Here are some key points to consider:

• Product Interactions: Be cautious if using products containing antihistamines meant for topical application, like diphenhydramine cream, ointment, or spray, as they may interact with this medication.

• Substance Interactions: Inform your healthcare provider if you are using any substances that could induce drowsiness. This includes opioid pain or cough medications (e.g., codeine, hydrocodone), alcohol, marijuana, sleep or anxiety medications (e.g., alprazolam, lorazepam, zolpidem), muscle relaxants (e.g., carisoprodol, cyclobenzaprine), or other antihistamines (e.g., cetirizine, diphenhydramine).

• Medication Labels: Carefully review the labels of all your medications, particularly those for allergies or cough-and-cold, as they may contain ingredients that cause drowsiness. Consult with your pharmacist to ensure you are using these products safely.

• Lab Test Interference: This medication may affect certain laboratory tests, such as urine drug screenings, potentially leading to inaccurate results. It is important to inform lab personnel and all your healthcare providers about your use of this medication to avoid misinterpretation of test outcomes.

Always follow medical advice and report any unusual symptoms to your healthcare provider promptly.

Some medications and products can interact with this drug, potentially affecting how it works or increasing side effects. These include skin-applied antihistamines like diphenhydramine cream, ointment, or spray. Inform your healthcare provider if you are using any other substances that could cause drowsiness. This includes opioid pain or cough medications (such as codeine, Hydrocodone), alcohol, marijuana, sleep or anxiety medications (like Alprazolam, Lorazepam, Zolpidem), muscle relaxants (such as Carisoprodol, Cyclobenzaprine), and other antihistamines (like Cetirizine, diphenhydramine).

It is important to read the labels on all your medications, especially those for allergies or cough-and-cold, as they may contain ingredients that induce drowsiness. Consult with your pharmacist for guidance on safe use of these products.

Additionally, this drug may interfere with certain laboratory tests, such as urine drug screenings, potentially leading to incorrect results. Ensure all your doctors and laboratory staff are aware that you are taking this medication.