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The use of this medication comes with important safety considerations and potential risks that must be understood before starting treatment. Please review the following information carefully and consult your healthcare provider if you have any concerns or questions.

• Low Sodium Levels: The use of desmopressin nasal spray can lead to dangerously low sodium levels, which may result in seizures, coma, respiratory arrest, or even death. To mitigate this risk, your healthcare provider will likely advise you to limit fluid intake and monitor your sodium levels before starting the medication. Be vigilant for symptoms such as headache, nausea, vomiting, fatigue, weight gain, muscle weakness, cramps or spasms, loss of appetite, or seizures, and inform your provider immediately if they occur. Individuals at higher risk include children, those aged 65 or older, individuals with conditions affecting fluid and electrolyte balance (such as heart failure or kidney disease), and those taking other medications that lower sodium levels.

• Poor Absorption: Desmopressin nasal spray may not be effective if you have nasal scarring, blockages, or have recently undergone nasal surgery, as these conditions can impede absorption. Long-term use of the spray can also lead to absorption issues. If you are affected, your healthcare provider might prescribe an alternative form of desmopressin, such as an oral or injectable version. This risk is particularly relevant for those with abnormal nasal mucosa or those who have used the spray for an extended period.

• Contraindications: There are specific circumstances under which desmopressin nasal spray should not be used due to serious health risks. These include poor kidney function and existing low sodium levels. If you have these conditions, consult your healthcare provider before using this medication.

This information is crucial for ensuring your safety while using desmopressin nasal spray. Always follow your healthcare provider’s guidance and report any adverse symptoms promptly.

When taking this medication, you may encounter some common side effects that are generally mild and manageable. These include headaches, sore throat, coughing, symptoms of a common cold, nausea, flushing, and mild stomach cramps. If these symptoms persist or become bothersome, it is advisable to speak with your healthcare provider.

In addition to the common side effects, there are other side effects that some users have reported. These can include sneezing, a stuffy nose, or a nosebleed. While these are not typically severe, you should contact your healthcare provider if you find them troubling or persistent.

There are also rare but serious side effects associated with this medication that require prompt medical attention. A significant drop in sodium levels in your body can lead to severe outcomes such as seizures, coma, or even death. Additionally, allergic reactions may occur, characterized by difficulty breathing, hives, or swelling of the face, lips, tongue, or throat. If you experience any of these serious symptoms, seek emergency medical care immediately.