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The safety information for Tri-Luma is crucial for users to understand potential risks and precautions. Please review the following points carefully and discuss any concerns with your healthcare provider:

• Allergic Reaction: Tri-Luma contains a sulfite, which can trigger serious allergic reactions in individuals with sulfite allergies. If you are aware of a sulfite allergy, inform your healthcare team prior to beginning treatment. Note that sulfites differ from sulfa, and many individuals with sulfa allergies may tolerate sulfites without issue.

• Skin Discoloration: Hydroquinone, an ingredient in Tri-Luma, may cause blue-black patches on the skin, particularly in Black individuals, though it can affect any race. This discoloration could be permanent. Immediately contact your healthcare provider if you observe unusual skin discoloration or worsening melasma, as early intervention can mitigate these effects.

• Adrenal Hormone Changes: Long-term use of Tri-Luma, which contains corticosteroids, can alter adrenal hormone levels, impacting various bodily functions. These changes might lead to skin thinning or a weakened immune system. Abrupt cessation after extended use may result in skin irritation. Always follow usage instructions carefully, and do not exceed the prescribed duration of use.

• Skin Irritation: Common side effects include skin redness, peeling, dryness, itching, and a burning sensation, typically occurring at the application site. If you experience severe skin reactions, such as rash or blisters, particularly in areas where Tri-Luma was not applied, contact your healthcare provider. Extreme weather conditions may exacerbate these effects.

This information serves as a guide to ensure safe use of Tri-Luma and to help manage any adverse reactions effectively.

When using this medication, some common side effects might occur, typically mild in nature. These include skin redness, which affects 41% of users, skin peeling or flaking at 38%, a burning sensation on the skin in 18% of cases, dry skin in 14%, and itchy skin affecting 11%. Acne, mild burning or stinging, and skin irritation are also reported. Should these symptoms persist or become bothersome, it's advisable to consult a healthcare provider for guidance.

There are other side effects to be mindful of, which may include spider veins, increased skin sensitivity, and changes in skin color. More serious side effects, although rare, require prompt medical attention. These include blistering, skin cracking or shedding, and severe skin reactions such as significant burning or swelling. Furthermore, if you notice any skin discoloration or develop small red bumps (folliculitis), contact a medical professional.

In rare instances, this medication can be absorbed into the bloodstream, leading to symptoms of excess corticosteroids such as unusual fatigue, weight loss, headaches, swelling of the ankles or feet, increased thirst or urination, and vision problems. These are more likely in children or when the medication is used extensively over large skin areas. Immediate medical attention is essential if you experience an allergic reaction, characterized by swelling of the face, tongue, or throat, difficulty breathing, severe dizziness, or an extensive rash. Always inform a healthcare provider if you encounter any side effects not listed here.