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Olezarsen is used along with a proper diet to help lower fats (triglycerides) in the blood. It is used by people who have a certain inherited condition (familial chylomicronemia syndrome) that causes high levels of triglycerides in the blood. It is also used by people with very high blood triglyceride levels to help reduce the risk of pancreas disease (pancreatitis). Olezarsen works by improving how well your body gets rid of triglycerides.