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Transcutaneous Electrical Nerve Stimulation (TENS) is generally considered safe, but some individuals may experience negative side effects. These can include skin irritation or redness at the site of electrode placement, muscle twitching, or discomfort from the electrical stimulation. It is important to follow the device instructions and consult with a healthcare professional if any adverse effects occur. TENS should not be used by individuals with pacemakers or other implanted electronic devices, and caution is advised for those who are pregnant or have epilepsy.

A TENS unit should not be used in certain areas and situations. It is unsafe to use a TENS unit on the head, neck, or near the eyes. It should also be avoided on the front of the neck, as it may cause laryngospasm or affect the carotid sinus. Additionally, it should not be used on broken or irritated skin, over tumors, or near the heart, especially in individuals with pacemakers or other implanted electronic devices. Pregnant individuals should avoid using it on the abdomen or lower back. It is important to consult with a healthcare professional before using a TENS unit, especially if there are any underlying health conditions.