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This medication is not intended for weight loss, and using it in such a manner can pose serious health risks. Below are important safety considerations and warnings that you should be aware of. Consult your healthcare provider if you have any questions or concerns.

• Not for Weight Loss: This medication, Adthyza (levothyroxine/liothyronine), is not effective for weight loss and is unsafe when used for this purpose. High doses or use without a thyroid condition can lead to severe, potentially life-threatening side effects, such as bone or heart issues, particularly when combined with other weight-loss drugs. Discuss appropriate weight management strategies with your healthcare provider.

• Heart Health Concerns: Excessive intake of Adthyza can lead to heart complications, especially in individuals with pre-existing heart conditions or those aged 65 and older. Seek immediate medical attention if you experience symptoms like rapid or irregular heartbeat, chest pain, or shortness of breath. Your healthcare provider may need to adjust your dosage. Higher risk applies to those with a history of heart disease and patients aged 65 or older.

• Adrenal Hormone Imbalance: Adthyza may affect adrenal hormone levels, exacerbating conditions like Addison's disease. It is crucial to have your adrenal hormone levels evaluated before starting treatment. If you notice symptoms such as stomach pain, muscle weakness, fatigue, nausea, or vomiting, seek medical help promptly.

• Impact on Diabetes: Thyroid hormone treatment can alter blood sugar regulation, necessitating potential adjustments in diabetes medication dosages. It is important to monitor your blood sugar levels regularly and consult your healthcare provider if you notice unusual levels. The provider may need to modify your medication regimen.

Contraindications: Avoid using this medication if you have the following conditions, as it may lead to significant health issues:

• Adrenal cortical insufficiency (a type of adrenal hormone disorder)
• Untreated thyrotoxicosis (an excess of thyroid hormones)
• As a standalone or adjunct treatment for weight loss

Always consult your healthcare provider before starting Adthyza, especially if you have any of the above conditions or are considering its use for weight loss.

When taking Adthyza, it's important to be aware of potential interactions with other medications and certain foods, as these can affect how well the treatment works. Here are some key interactions to consider:

Medications That May Interact with Adthyza:

• Blood Thinners (Oral Anticoagulants): Adthyza can alter the effectiveness of blood-thinning medications. If you're on such treatments, your doctor may need to adjust your dosage and will monitor your blood clotting levels closely.

• Diabetes Medications (Insulin or Oral Hypoglycemics): Starting Adthyza may change your blood sugar levels, potentially requiring adjustments to your diabetes medication. Regular monitoring of blood glucose is recommended during this period.

• Cholesterol-Lowering Agents (Cholestyramine or Colestipol): These medications can bind to thyroid hormones in the gut, reducing Adthyza's absorption. To minimize this effect, take Adthyza at least four to five hours before or after these medications.

• Estrogen-Containing Products (Estrogen, Oral Contraceptives): Estrogens can increase the levels of proteins that bind thyroid hormones, potentially decreasing the amount of free (active) hormone in your body. If you start or stop estrogen therapy while on Adthyza, your doctor may need to adjust your thyroid medication dosage.

Food and Lifestyle Considerations:

• Certain Foods: Foods like soybean flour, soy-based products, high-fiber diets, cottonseed meal, and walnuts can interfere with the absorption of Adthyza. It's advisable to avoid consuming these foods close to the time you take your medication.

• Timing of Meals: To ensure optimal absorption, take Adthyza on an empty stomach with a full glass of water, ideally 30 to 60 minutes before eating.

• Enteral (Tube) Feedings: If you're receiving nutrition through a feeding tube, be aware that this can affect how your body absorbs Adthyza. It's recommended to take Adthyza at least one hour before tube feedings to maintain its effectiveness.

Always inform your healthcare provider about all medications, supplements, and dietary habits to ensure Adthyza works effectively and safely for you.