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Vutrisiran is used to treat a certain type of heart failure or nerve problems due to a certain inherited condition (transthyretin-mediated amyloidosis). This condition causes a protein that your body normally makes (transthyretin-TTR), to change shape and build up in different parts of your body, which can affect the nerves, heart, and stomach/intestines. This medication works by decreasing the buildup of TTR in your body. In people with heart failure, it may help lower the risk of death from heart disease, prevent the worsening of heart failure, and decrease the need to go to a hospital to treat heart failure.