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The following safety information outlines crucial warnings and contraindications for the use of Arformoterol (Brovana). It is important to thoroughly review this information and discuss any concerns with your healthcare provider.

• Asthma Use: Arformoterol (Brovana) is not suitable for individuals with asthma. Its safety and efficacy in treating asthma have not been established. Alternative inhalers specifically designed for asthma treatment should be considered.

• Bronchospasm Risk: There is a rare risk of experiencing a bronchospasm, a muscle spasm in the lungs, which can result in breathing difficulties, wheezing, coughing, and chest discomfort. Seek immediate medical attention if you experience shortness of breath after using Arformoterol (Brovana).

• Cardiac Concerns: This medication can affect blood pressure and heart rate, potentially worsening pre-existing heart conditions. If you have hypertension or other heart-related issues, monitor for symptoms such as dizziness, fatigue, tremor, rapid heartbeat, or weakness. Overuse of Arformoterol (Brovana) can exacerbate these risks. Inform your healthcare provider if you experience these symptoms.

• Allergic Reactions: Allergic reactions, including severe reactions like facial swelling, shock, and anaphylaxis, may occur. Immediate medical assistance is required if you experience hives, rash, red skin, swelling of the lips or tongue, or difficulty breathing following use.

Contraindications:

• Asthma without Corticosteroids: Do not use Arformoterol (Brovana) without an inhaled corticosteroid if you have asthma, as this can present significant health risks. Always consult with your healthcare provider regarding the appropriate treatment plan.

Common side effects:

• nervousness
• dizziness
• tremors
• headaches
• nausea
• dry mouth
• trouble sleeping
• general pain
• chest pain
• back pain
• diarrhea
• sinus infections

Less common but important to monitor:

• leg cramps
• shortness of breath
• rash
• flu-like symptoms
• swelling in the arms, legs, or feet
• increase in blood pressure
• muscle cramps
• increased thirst or urination
• changes in voice
• dehydration
• fast heart rates
• chest congestion
• rapid or irregular heartbeat

Serious side effects:

• sudden breathing difficulties
• wheezing
• paradoxical bronchospasm
• serious allergic reaction
• swelling of the face, lips, or tongue
• difficulty breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Formoterol
• salmeterol

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• methacholine