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When considering the use of prednisone, it is crucial to understand the associated safety information and warnings. Please review the following points and discuss any concerns with your healthcare provider.

• Increased Risk of Infections: Long-term or high-dose use of prednisone may heighten your susceptibility to infections and obscure their symptoms. Avoid exposure to individuals with chickenpox or measles. If you have a history of tuberculosis (TB), your healthcare provider will need to monitor you to prevent a recurrence, potentially with antibiotics. Discuss vaccinations with your healthcare provider, as some may be ineffective or unsafe during prednisone treatment. Notify your healthcare provider if you feel unwell. Risks include concurrent use of immune-suppressing drugs, unvaccinated status, and receiving live vaccines.

• Mood and Behavior Changes: Prednisone may result in mood alterations. Contact your healthcare provider immediately if you experience depression, mood swings, insomnia, anxiety, or hallucinations. This risk is heightened for those with a history of mental health issues.

• Adrenal Gland Suppression: Prolonged use can suppress adrenal gland function, leading to steroid withdrawal symptoms like fatigue, joint or muscle pain, and low energy if the medication is abruptly reduced or stopped. Consult your healthcare provider before changing your dosage. Risks include high-dose usage, prolonged treatment, young children, and stress from trauma or infection.

• Heart and Kidney Function Alterations: Prednisone may cause high blood pressure, fluid retention, and affect kidney function, potentially worsening conditions such as hypertension, heart failure, and renal issues. Discuss your medical history with your healthcare provider to ensure prednisone is safe for you. Risks include existing heart or kidney conditions.

• Gastrointestinal Issues: There is an increased risk of stomach damage, including irritation, ulcers, and bleeding. Avoid alcohol as it can exacerbate these problems. Seek prompt medical attention for persistent stomach pain or bloody stools. Risks include a history of gastrointestinal issues or concurrent use of NSAIDs.

• Bone Health Concerns: Long-term prednisone use can weaken bones, increasing the risk of osteoporosis and fractures, and may slow growth in children. Monitor your child's growth during treatment and discuss bone health with your healthcare provider. Risks include prolonged high-dose use, female sex, smoking, and a history of falls.

• Eye Health Risks: Extended use may elevate the risk of cataracts, glaucoma, and certain eye infections. Notify your healthcare provider if you experience vision changes or have a history of eye conditions such as herpes simplex. Regular eye exams may be necessary for long-term users. Risks include previous eye health issues.

• Contraindications: Do not use prednisone if you have a systemic fungal infection, as it may pose serious health risks. Consult your healthcare provider for guidance.

Ensure to follow these guidelines and consult with your healthcare provider for personalized advice before using prednisone.

When taking this medication, it's important to be aware of potential side effects. Common side effects include nausea, vomiting, heartburn, increased appetite, and weight gain. These effects are generally mild and often temporary. Some people may also experience acne, muscle weakness, or insomnia. If these symptoms persist or worsen, it is advisable to consult a healthcare provider.

More serious side effects, though rare, can occur and require prompt medical attention. These include symptoms such as bone pain, easy bruising or bleeding, changes in menstrual periods, and mood alterations like depression or agitation. Swelling in the face, hands, or feet, slow wound healing, thinning skin, and unusual weight gain are also potential concerns. Vision problems, symptoms of stomach or intestinal bleeding, or red/purple spots on the skin should be reported to a doctor immediately.

This medication may also affect blood sugar levels, potentially causing or exacerbating diabetes. Signs of high blood sugar include increased thirst and urination. Individuals with diabetes should monitor their blood sugar closely and discuss any changes with their doctor.

Though very rare, serious allergic reactions can occur, presenting as rash, severe dizziness, swelling, or trouble breathing. Immediate medical help is essential if these symptoms arise. While this list includes many potential side effects, it is not exhaustive. If you experience any other unusual symptoms, reach out to a healthcare professional for advice.

Prednisone can interact with several other medications, which may require adjustments to your treatment plan. It's important to inform your doctor and pharmacist about all the prescription and over-the-counter medications, vitamins, and supplements you are taking.

Certain drugs, like Desmopressin and the Rotavirus Vaccine, Live, should generally not be used with Prednisone. Your doctor might choose an alternative treatment if you're taking these.

There are medications that are usually not recommended with Prednisone, but in some cases, they might be necessary. If prescribed together, your doctor could adjust the dosage or frequency. These include Aldesleukin, Amiodarone, and a wide range of other medications like Celecoxib and Ibuprofen.

Additionally, using Prednisone with some drugs might increase the risk of side effects, but could be essential for your health. In these instances, your doctor may modify how you use the medications. Examples are Aspirin, Warfarin, and Licorice.

Prednisone could also interfere with certain lab tests, such as allergy skin tests, potentially leading to inaccurate results. Ensure that all healthcare providers and laboratory staff are aware that you are taking this medication. Always follow your doctor's guidance, especially when taking low-dose aspirin for heart attack or stroke prevention, unless advised otherwise.