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This document outlines essential safety information for armodafinil (Nuvigil). Please read these warnings thoroughly and consult your healthcare provider if you have any questions or concerns.

• Allergic Reactions: Although rare, armodafinil (Nuvigil) can trigger serious allergic reactions, including facial, eye, lip, tongue, or throat swelling, which may lead to breathing difficulties. These reactions could also affect the liver or blood cells, with symptoms like fever, rash, weakness, or jaundice (yellowing of the skin or eyes). Seek immediate medical attention if these symptoms occur, particularly if you have previously reacted to armodafinil (Nuvigil).

• Severe Skin Reactions: In rare cases, armodafinil (Nuvigil) can cause severe and potentially life-threatening skin conditions. Discontinue use and seek medical help promptly if you develop a new rash, sores, blisters, or skin peeling, especially around the lips or inside the mouth.

• Driving Impairment: Armodafinil (Nuvigil) can affect concentration, thought processes, and reaction times. Despite increasing wakefulness, some individuals might still struggle with extreme sleepiness. Until you understand how the medication impacts you, avoid tasks that require full alertness, like driving or operating machinery. This risk increases with alcohol consumption or when taken with other sedatives.

• Cardiac Concerns: The use of armodafinil (Nuvigil) may result in chest pain, irregular heartbeat, or shortness of breath, particularly in individuals with pre-existing heart conditions or those taking higher doses. Healthcare providers may advise monitoring blood pressure and heart rate during treatment.

• Mental Health Symptoms: Some users of armodafinil (Nuvigil) have reported mental health issues, such as depression, hallucinations, mania, or suicidal thoughts. Be vigilant for any signs of worsening depression or unusual mood or behavior changes, especially if you have a history of mental health disorders.

Please ensure you understand these risks and take appropriate precautions while using armodafinil (Nuvigil). Always follow your healthcare provider's guidance.

Common side effects:

• Headache
• Nausea
• Dizziness
• Dry mouth
• Nervousness
• Difficulty sleeping
• Anxiety
• Diarrhea
• Fatigue

Less common but important to monitor:

• Upset stomach
• Indigestion
• Changes in heartbeat

Serious side effects:

• Serious allergic reaction
• Fever
• Swollen lymph nodes
• Rash
• Itching
• Swelling (especially of the face, tongue, or throat)
• Severe dizziness
• Trouble breathing
• Chest pain
• Irregular heartbeat
• Worsening depression
• Mania
• Suicidal thoughts

Interactions with high risk of serious adverse effects and should be avoided:

• Methamphetamine
• MDMA (ecstasy)
• Hormonal birth control (such as pills, patches, or rings)
• Modafinil

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Caffeine
• Midazolam
• Omeprazole

Interactions with low risk that usually do not require a change in therapy:

• Cough-and-cold products or diet aids