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This medication carries important safety considerations that you should be aware of. Please review the following points carefully and discuss any concerns with your healthcare provider:

• Addiction, Misuse, and Dependence: Methamphetamine (Desoxyn) has the potential for addiction, misuse, and dependence. Always use it strictly as prescribed by your healthcare provider. Misuse can increase the risk of overdose and serious side effects. Abruptly stopping methamphetamine (Desoxyn) may lead to withdrawal symptoms such as irritability, nightmares, and sleep disturbances. Those with a history of substance or alcohol use disorder are at heightened risk.

• Serious Heart Problems: There are reports of sudden death, stroke, and heart attack associated with usual doses of methamphetamine (Desoxyn). Notify your healthcare provider of any pre-existing heart conditions before starting this medication, as alternatives might be safer. Methamphetamine can increase blood pressure and heart rate, so regular monitoring is recommended. Seek medical attention if you experience fainting, chest pain during physical activity, or an irregular heartbeat.

• Behavioral and Mental Health Changes: Methamphetamine (Desoxyn) can trigger mental health issues such as hallucinations, unclear thinking, and mania, and may exacerbate existing mood disorders. Inform your provider immediately if you notice any mood or behavior changes, especially if you have a history of psychosis, bipolar disorder, or depression.

• Seizures: Methamphetamine (Desoxyn) can increase the risk of seizures, although this is uncommon. If a seizure occurs, seek immediate medical assistance and discontinue use.

• Blood Circulation Issues (Raynaud's Phenomenon): Methamphetamine may contribute to blood circulation problems, leading to symptoms like numbness or pain in fingers and toes. Inform your provider if you experience these symptoms, as a dosage adjustment or alternative treatment might be necessary.

• Growth Concerns in Children: Methamphetamine (Desoxyn) may slow growth and cause weight loss in children. Healthcare providers will monitor growth closely and may modify treatment if necessary.

• Serotonin Syndrome: Using methamphetamine (Desoxyn) alongside other medications that affect serotonin, such as certain antidepressants, can lead to serotonin syndrome, a potentially life-threatening condition. Be vigilant for symptoms like rapid heartbeat, sweating, muscle stiffness, high fever, and confusion, and seek urgent medical care if they occur.

• Motor and Verbal Tics: Methamphetamine (Desoxyn) may cause or worsen tics, including those associated with Tourette’s syndrome. Report any new or worsening tics to your healthcare provider.

Contraindications:

• Do not use methamphetamine (Desoxyn) if you have a severe allergy to amphetamine-containing products or if you have used a monoamine oxidase inhibitor (MAOI) within the past 14 days.

Always communicate openly with your healthcare provider about your medical history and any medications you are taking to ensure safe and effective use of methamphetamine (Desoxyn).

Common side effects:

• Dry mouth
• Nausea
• Upset stomach
• Diarrhea
• Constipation
• Dizziness
• Weight loss
• Trouble sleeping
• Headache
• Low appetite

Less common but important to monitor:

• High blood pressure
• Fast heartbeat
• Restlessness
• Tremors
• Uncontrolled muscle movements
• Changes in libido
• Stomach upset

Serious side effects:

• Chest pain
• Severe headache
• Symptoms resembling a heart attack or stroke
• Agitation
• Mood swings
• Hallucinations
• Thoughts of self-harm
• Serotonin syndrome
• Severe allergic reactions (rash, swelling, difficulty breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Isocarboxazid
• Linezolid
• Methylene Blue
• Moclobemide
• Phenelzine
• Procarbazine
• Rasagiline
• Safinamide
• Selegiline
• Tranylcypromine

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Fluoxetine
• Paroxetine
• Duloxetine
• Venlafaxine
• MDMA (ecstasy)
• St. John's wort
• Cough-and-cold products
• Diet aids
• NSAIDs (e.g., ibuprofen, naproxen)