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This medication requires careful handling and administration to ensure safety and efficacy. Below are important safety warnings and precautions to consider:

• Administration Warning: Do not inject this medication into a vein or mix it with intravenous solutions. It must be administered deeply into a large muscle, such as the upper outer quadrant of the buttock or the thigh, to prevent serious complications like heart and lung issues or accidental injection into an artery or nerve, which could cause severe tissue injury or nerve damage.

• Severe Allergic Reactions (Anaphylaxis): If you have a history of severe allergies to penicillin or cephalosporin antibiotics, consult your healthcare provider before using this medication. Symptoms like difficulty breathing or facial swelling require immediate medical attention.

• Severe Skin Reactions: Rare but potentially life-threatening skin reactions can occur. Seek medical help immediately if you develop a new rash, fever-associated rash, unexplained blisters, or new sores in your mouth.

• C. difficile Diarrhea: Be aware of the risk of developing severe diarrhea due to a bacterial infection, which may occur up to two months after completing the medication. Contact your healthcare provider if you experience severe watery stools.

• Blood Disorder (Methemoglobinemia): This condition may occur when using local anesthetics like procaine with this medication. Symptoms include discolored skin, headache, rapid heartbeat, shortness of breath, lightheadedness, or fatigue. Seek urgent medical attention if these occur. Inform your healthcare provider about any medications you are taking, especially if you have conditions like glucose-6-phosphate dehydrogenase deficiency, or a history of methemoglobinemia or related heart or lung conditions.

• Contraindications: Do not use this medication if you have a known allergy to any penicillin antibiotic.

These precautions are critical for ensuring safe use of the medication. Always consult your healthcare provider if you have concerns or experience any adverse effects.

When using this medication, some common side effects may occur, such as pain at the injection site, nausea, and vomiting. Typically, these are mild and temporary, but if they persist or worsen, consult your healthcare provider. Occasionally, more serious side effects can arise, including nerve problems, kidney issues, headaches, and changes in vision. It's also possible to experience dizziness, fainting, or breathing difficulties, which should prompt immediate medical attention.

Rarely, a blood disorder known as methemoglobinemia may develop, characterized by pale or bluish skin, headache, confusion, and shortness of breath. If these symptoms appear, seek urgent care. Similarly, severe allergic reactions, such as difficulty breathing or swelling in the face and neck, require immediate medical intervention. Some individuals may also experience severe skin reactions, marked by rash, fever, or blisters, as well as potential intestinal injuries or infections at the injection site.

Additional side effects can include joint or muscle pain, unusual bleeding or bruising, and changes in mental health, such as depression or agitation. In some cases, prolonged use of the medication might lead to oral thrush or yeast infections. If you notice any new or persistent symptoms, contact your healthcare provider for guidance. Remember, while this list covers many potential side effects, it is not exhaustive, and any other concerns should be discussed with a medical professional.

It is important to be aware that Bicillin CR can interact with various medications and supplements. Inform your doctor and pharmacist about all the drugs and supplements you are taking, including those prescribed, over-the-counter, vitamins, and herbal products. Some medications that may have significant interactions with Bicillin CR include Methotrexate, alfentanil, amifampridine, Amiodarone, among others. If your healthcare provider prescribes these together, they may adjust the dosage or frequency to minimize interaction risks.

Additionally, this drug may affect the results of certain lab tests, such as urine glucose tests, potentially leading to incorrect results. Ensure that your healthcare team, including lab personnel, are aware that you are using this medication to prevent misinterpretation of test outcomes.