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Bleomycin

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Bleomycin is a chemotherapy drug used to treat various types of cancer, including Hodgkin and Non-Hodgkin lymphoma, testicular cancer, cervical cancer, certain head and neck cancers, and cancers of the penis and vulva. It is also utilized to manage malignant pleural effusion, a condition where cancer cells accumulate between the chest wall and lungs. Bleomycin works as an "antitumor antibiotic," primarily by damaging the DNA and RNA of cancer cells. This damage prevents the cells from growing and spreading effectively. It is typically administered through an intravenous injection as part of a broader chemotherapy treatment plan. While Bleomycin can be effective in halting cancer progression, it may cause side effects such as fatigue and decreased appetite. There is also a significant risk of lung toxicity, which can sometimes lead to pulmonary fibrosis. It is important to discuss its use and potential risks with your healthcare provider.
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Bleomycin WarningsBleomycin Side EffectsBleomycin InteractionsFAQs

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15UNIT, Bleomycin (30 Solution Reconstituteds)

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Walgreens

$364.99

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Bleomycin savings card

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Bleomycin dosage forms

The average cost for 30 Solution Reconstituteds of Bleomycin at 15UNIT is $364.99 with a free coupon. This is 25.86% off the average retail price of $1411.5
DosageQuantityPrice fromPer unit
15UNIT30 Solution Reconstituteds$364.99$12.17
30UNIT30 Solution Reconstituteds$747.58$24.92

Bleomycin Warnings

Bleomycin is a medication that comes with several important safety warnings and precautions that you should be aware of before starting treatment. These precautions are crucial to ensure your safety and reduce the risk of serious side effects. Please review the following information carefully and consult your healthcare provider if you have any concerns:

  • Healthcare Supervision Required: Bleomycin should only be administered under the supervision of a healthcare professional trained in its use. Your medical team will monitor your treatment closely to ensure your safety.

  • Serious Lung Risks: Bleomycin can cause severe lung problems, including pulmonary fibrosis, which is characterized by scarring and stiffness of the lung tissue. This condition can lead to difficulty breathing. Patients over the age of 70 or those who receive multiple doses or exceed the maximum lifetime dose of 400 units are at a higher risk. Regular breathing tests will be conducted to monitor your lung function. Report any new symptoms such as a cough, chest pain, or difficulty breathing to your healthcare provider immediately.

  • Allergic-like Reactions: Rarely, bleomycin can trigger a serious reaction similar to anaphylaxis, known as an idiosyncratic reaction. Symptoms may include trouble breathing, chills, confusion, dizziness, fainting, and low blood pressure. This typically occurs around the time of infusion. Your healthcare team will monitor you closely, especially during the initial doses. If a reaction occurs, medications like diphenhydramine or corticosteroids may be administered.

  • Pregnancy Warning: Bleomycin could harm an unborn baby or increase the risk of miscarriage. Avoid pregnancy during treatment, and inform your healthcare provider immediately if you become pregnant.

  • Kidney and Liver Monitoring: Bleomycin can affect kidney and liver function. Regular lab tests will be conducted to monitor these organs. Discuss any existing kidney or liver concerns with your provider to ensure the medication is safe for you.

  • Contraindications: Bleomycin should not be used in individuals who have previously experienced an allergic or idiosyncratic reaction to the drug. If this applies to you, consult your healthcare provider for alternative treatments.

In case of overdose, seek emergency medical attention immediately. Always follow your healthcare provider's instructions and report any adverse effects promptly to ensure your safety while using bleomycin.

Bleomycin Side Effects

Pain/redness at the injection site, fever, chills, vomiting, loss of appetite, weight loss, darkening of the skin, or changes in fingernails/toenails may occur. Changes in diet such as eating several small meals or limiting activity may help lessen some of these effects. In some cases, drug treatment may be necessary to prevent or relieve nausea and vomiting. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Temporary hair loss may occur. Normal hair growth should return after treatment has ended. People using this medication may have serious side effects. However, you have been prescribed this drug because your doctor has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk. Painful sores on the lips, mouth, and throat may occur. To decrease the risk, limit hot foods and drinks, brush your teeth carefully, avoid using mouthwash that contains alcohol, and rinse your mouth often with cool water. Bleomycin can commonly cause skin reactions (such as redness, itching, blisters, rash, swelling), usually in the second or third week of treatment. These reactions are not always serious. However, you may not be able to tell them apart from signs of a severe reaction. Tell your doctor right away if you develop any skin reaction. Tell your doctor right away if you have any serious side effects, including: nausea that doesn't stop, dizziness/fainting, fast/pounding heartbeat, numbness/tingling, feeling of coldness in hands/feet, easy bruising/bleeding, pale/bluish skin, coughing up blood, vomit that looks bloody or like coffee grounds, signs of infection (such as sore throat that doesn't go away, fever, chills), signs of kidney problems (such as change in the amount of urine, pink urine), mental/mood changes (such as confusion, aggression), stomach/abdominal pain, dark urine, yellowing eyes/skin. Get medical help right away if you have any very serious side effects, including: weakness on one side of the body, vision changes, trouble speaking, chest pain. A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: confusion, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Bleomycin Interactions

Interactions with high risk of serious adverse effects and should be avoided:

  • Brentuximab Vedotin

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

Bleomycin FAQs
What is the most feared complication of bleomycin administration?

The most feared complication of bleomycin administration is pulmonary toxicity, which can lead to pulmonary fibrosis. This condition can result in significant respiratory issues and is a serious concern during treatment with bleomycin.

Bleomycin works by binding to DNA and causing breaks in the DNA strands. This action inhibits DNA synthesis and, to a lesser extent, RNA and protein synthesis, leading to cell death. It is particularly effective in targeting rapidly dividing cancer cells, which is why it is used in the treatment of certain types of cancer, such as Hodgkin's lymphoma, testicular cancer, and some types of head and neck cancers.

Bleomycin can cause pulmonary toxicity, which is one of its most significant adverse effects. This toxicity can manifest as pneumonitis and, in severe cases, progress to pulmonary fibrosis. It is important to monitor lung function in patients receiving bleomycin to detect any early signs of pulmonary complications.

Bleomycin is used primarily in the treatment of certain types of cancer. It is commonly used to treat Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular cancer, and certain types of head and neck cancers. It may also be used in the treatment of malignant pleural effusion.

The most serious side effect of bleomycin is pulmonary toxicity, which can lead to pulmonary fibrosis. This condition can cause significant respiratory issues and may be life-threatening. It is important for patients receiving bleomycin to be closely monitored for any signs of lung problems.

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