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This medication carries several important safety warnings that you should be aware of. Below is a summary of potential risks and precautions associated with its use. It is essential to discuss any concerns with your healthcare provider.

• Kidney Damage: Cisplatin may cause kidney damage, and in severe cases, kidney failure. To mitigate this risk, you will receive fluid infusions before, during, and after each treatment. Your healthcare provider will monitor your kidney function closely. If you notice blood in your urine, difficulty or pain while urinating, or changes in urine color or cloudiness, contact your provider immediately, as these could indicate kidney issues. Those at higher risk include individuals on higher doses, those undergoing prolonged treatment, people over 65, those with a history of kidney problems, and those taking other kidney-affecting medications.

• Nerve Issues: This drug can lead to new or worsening nerve problems, particularly in the extremities. These symptoms might start after the initial dose or even weeks post-treatment and may persist. Report any numbness, pain, burning, tingling, tremors, balance issues, or limb weakness to your healthcare provider. Higher doses and longer treatment durations increase the risk, especially for patients over 65.

• Nausea and Vomiting: Significant nausea and vomiting may occur, typically starting a few hours after the infusion and lasting up to three days or longer. Anti-nausea medication will be provided to help prevent these symptoms. Follow your provider’s instructions on medication use at home.

• Low Blood Cell Counts: Treatment can reduce red and white blood cells and platelets, increasing the risk of anemia, infections, and bleeding. In some cases, low blood cell counts may persist due to bone marrow suppression. Older adults are particularly at risk.

• Allergic Reactions: Cisplatin may cause serious allergic reactions, including anaphylaxis. The risk is higher with increased dosages. If you’ve had allergic reactions to similar drugs, inform your provider. Seek immediate medical attention if you experience throat tightness, breathing difficulties, facial swelling, fever, chills, hives, flushing, chest pain, rapid heartbeat, or dizziness.

• Hearing Loss: Repeated doses can lead to hearing issues, which may affect one or both ears and can be more severe in children under 5. Baseline and regular hearing tests will be conducted. Report any ear ringing or hearing changes to your provider. Risk factors include concurrent use of other ototoxic drugs, prior kidney problems, and brain radiation.

• Eye Problems: Although rare, some patients may experience vision changes, which are usually reversible post-treatment. Notify your provider about any vision issues.

• Secondary Cancer Risk: A rare potential exists for developing secondary cancers, such as blood cancers, following treatment with cisplatin. Discuss any concerns with your provider.

• Pregnancy Risks: Cisplatin can harm an unborn baby. Use effective contraception during treatment and for 11 months after treatment for men, and 14 months for women. Report any pregnancy immediately.

• Injection Site Injury: Cisplatin may leak during infusion, causing irritation or damage to nearby tissue. Inform your provider or nurse if you experience pain, swelling, or burning at the injection site.

These warnings are not exhaustive. Always consult your healthcare provider for comprehensive medical advice tailored to your situation.

Common side effects:

• Nausea
• Vomiting
• Changes in hearing
• Abnormal blood cell counts
• Numbness or tingling in hands or feet

Serious side effects:

• Repeated fevers
• Chills
• Cough
• Trouble breathing
• Severe diarrhea
• Painful or frequent urination
• Serious bleeding or bruising that doesn't stop
• Large amounts of bleeding
• Blood in the urine
• Vomiting blood
• Black and tarry stools
• Kidney problems