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Here is important safety information regarding the use of this medication. Please carefully read through the details and consult your healthcare provider if you have any questions or concerns.

• Medication Interactions: Prior to starting norethindrone, inform your healthcare provider or pharmacist about all the medications and supplements you are currently taking. This will allow them to identify any potential interactions with norethindrone.

• Ectopic Pregnancy or Ovarian Cyst: There is a slight risk of an ectopic pregnancy, which occurs outside the uterus, if you become pregnant while taking norethindrone. This condition can be serious, so seek immediate medical attention if you experience symptoms like cramping or pain in the lower abdomen or shoulder area.

• Irregular Vaginal Bleeding: While using norethindrone, it is common to experience irregular vaginal bleeding. In rare cases, this may indicate a serious condition such as an infection or cancer. Discuss any concerns about irregular bleeding with your healthcare provider. If you experience no vaginal bleeding, consult your provider to rule out pregnancy.

• Possible Cancer Risk: Some studies suggest that combination birth control pills may increase the risk of breast or ovarian cancer. It is unclear if norethindrone or other progestin-only pills (POPs) carry the same risk. If you have concerns about cancer risk, consult with your healthcare provider.

Contraindications are specific conditions or factors where the use of this medication is not recommended due to potential serious health risks. If any of the following apply to you, please consult your healthcare provider before using this medication:

• Pregnancy
• Known or suspected breast cancer
• Unexplained vaginal bleeding
• Liver tumors (benign or cancerous)
• Acute liver disease

When taking this medication, some people may experience mild side effects such as nausea, vomiting, headaches, bloating, weight gain, and breast tenderness. There might also be changes in menstrual cycles, including spotting or irregular periods. These side effects are generally not serious but if they persist or worsen, it's advisable to consult a healthcare provider for guidance.

On the other hand, there are more serious side effects that require immediate medical attention. These include the development of lumps in the breast, mood changes like worsening depression, severe abdominal pain, dark urine, yellowing of the skin or eyes, and unusual bleeding patterns such as continuous spotting or sudden heavy bleeding. A rare but serious risk is an allergic reaction, which could manifest as a rash, itching, swelling, severe dizziness, or trouble breathing.

A very rare yet severe condition that could arise is ectopic pregnancy, which may present as severe stomach pain and spotting. If any of these severe symptoms occur, it's crucial to seek medical help right away to ensure prompt and appropriate care. Always stay informed about potential side effects and communicate any concerns with a healthcare provider.