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Mavacamten, also known as Camzyos, is a medication with potential risks that require careful consideration and monitoring. Below are the key safety warnings and precautions you should be aware of:

• Risk of Heart Failure: Mavacamten may lead to heart failure, especially if you have an irregular heartbeat, a serious infection, or are taking other medications that increase heart failure risk. It can also impair the heart's ability to pump blood effectively. Your healthcare provider will conduct heart function tests (ejection fraction) before and during treatment. If your heart function declines, treatment may be stopped. Seek immediate medical attention if you notice symptoms like difficulty breathing, fatigue, weakness, or swelling in your hands and feet.

• Drug Interactions: This medication interacts with many commonly used drugs and supplements. Certain medications, such as phenytoin and rifampin, can decrease the effectiveness of mavacamten, while others, like diltiazem and clarithromycin, can increase the risk of heart failure. Always inform your healthcare provider about all medications and supplements you are taking, and consult them before starting any new treatments.

• Pregnancy Risks: Mavacamten should not be used during pregnancy due to the risk of severe harm to an unborn child. It can also interfere with hormonal contraceptives, reducing their effectiveness. Women of childbearing potential should use non-hormonal birth control while taking mavacamten and for four months after the last dose. If you become pregnant while on this medication, contact your healthcare provider immediately.

• Regulatory Requirements: In the United States, adherence to the REMS Program for mavacamten is mandatory. If residing outside the U.S., consult your healthcare provider for the relevant regulations in your country.

In the event of an overdose, seek emergency medical assistance promptly. Always adhere to your healthcare provider's instructions and discuss any concerns or questions you may have regarding the use of mavacamten.

When taking this medication, you might experience dizziness, which is a common side effect affecting some individuals. This is usually mild, but if it persists or worsens, it's important to reach out to your healthcare provider for guidance. Additionally, fainting has been reported by some users, so please be vigilant and consult your healthcare provider if this occurs.

Although rare, there are serious side effects that demand immediate medical attention. These include signs of heart failure, such as trouble breathing, persistent cough, wheezing, swelling in the legs and ankles, an irregular or rapid heartbeat, difficulty exercising, fatigue, weakness, or abdominal swelling. If you experience any of these symptoms, seek urgent medical care.

A very serious allergic reaction is also uncommon but can occur. Be alert to symptoms like a rash, itching or swelling, particularly of the face, tongue, or throat, severe dizziness, and trouble breathing. These require prompt medical intervention.

This summary does not cover all possible effects. If you notice other symptoms or have concerns, reaching out to your healthcare provider is advisable.