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This medication contains important safety information regarding potential risks and precautions. Please read the following points carefully and discuss any concerns with your healthcare provider:

• Orthostatic Hypotension: Initiating treatment with doxazosin (Cardura) or increasing the dosage may lead to a sudden drop in blood pressure when standing up, known as orthostatic hypotension. This condition can cause symptoms like dizziness, lightheadedness, blurry vision, fainting, nausea, and confusion. The body generally adapts within a few days, but persistent symptoms should be reported to your healthcare provider. Immediate medical attention is necessary if a fall results in head injury. Be cautious when transitioning from sitting to standing, especially if dehydrated, consuming alcohol, taking other blood pressure medications, or if you have heart failure. Older adults are particularly at risk.

• Prolonged and Painful Erection: Doxazosin (Cardura) may rarely cause prolonged and painful erections that could require surgical intervention. If you experience an erection lasting more than 4 hours, discontinue the medication and seek immediate medical care.

• Eye Complications: The medication can lead to intraoperative floppy iris syndrome (IFIS) during cataract surgery, increasing the risk of complications. It is crucial to inform your eye surgeon if you are taking doxazosin (Cardura) so they can adjust your treatment plan accordingly, even if you have stopped the medication. This is particularly important if you have planned cataract surgery.

• Digestive System Concerns with Cardura XL: Rare cases of intestinal blockages have been reported with extended-release formulations similar to Cardura XL (doxazosin). Report symptoms such as severe stomach pain, bloating, nausea, or vomiting to your healthcare provider, especially if you have a history of stomach issues.

Please consult your healthcare provider before making any changes to your medication regimen.

When taking this medication, some common side effects may occur, including dizziness, which affects between 16-19% of users, and fatigue, reported by 8-12%. These are generally mild and should not cause alarm, but if they persist or worsen, consulting a healthcare provider is advisable. Occasionally, users may experience headaches, dizziness (5%), respiratory tract infections (5%), or feeling weak (4%). These effects are typically mild, yet monitoring them is important.

For more serious side effects, urgent medical attention is necessary. Such effects include sleepiness, low blood pressure, shortness of breath, and dry mouth. Swelling is also a serious concern and should prompt immediate consultation with a healthcare professional. Rarely, males may experience a painful or prolonged erection lasting four or more hours; if this occurs, discontinue use and seek medical help right away to prevent permanent issues.

In very rare instances, a severe allergic reaction may occur, characterized by rash, itching or swelling, particularly of the face, tongue, or throat, severe dizziness, or trouble breathing. Any of these symptoms require immediate medical intervention. It's important to remember that while these side effects may seem daunting, many individuals using this medication do not experience serious issues. Always communicate with a healthcare provider if you notice any side effects not listed here.

Doxazosin (Cardura) can interact with various medications, and it's essential to inform your healthcare provider about any other drugs or supplements you're taking, including prescribed medications, over-the-counter drugs, vitamins, and herbal supplements.

Key Drug Interactions:

1. Alpha Blocker Drugs: Combining doxazosin with other alpha blockers like Prazosin or Tamsulosin may affect your treatment plan, and your doctor might need to adjust your medications accordingly.

2. Erectile Dysfunction and Pulmonary Hypertension Medications: Using doxazosin with drugs such as Sildenafil or Tadalafil may lower your blood pressure significantly, potentially causing dizziness or fainting. Your doctor must monitor and possibly adjust your dosages to manage this risk.

3. Other Medications Affecting Doxazosin Metabolism: Drugs like azole antifungals (e.g., Itraconazole, Ketoconazole), macrolide antibiotics (e.g., Clarithromycin), and HIV protease inhibitors (e.g., lopinavir, Ritonavir) can influence how doxazosin is processed in your body. This might change the effectiveness of doxazosin.

4. Beta Blockers and Related Drugs: Medications such as Atenolol, Bisoprolol, and Propranolol, as well as others used for managing blood pressure and heart conditions, may increase the risk of side effects when taken with doxazosin. Your doctor might need to adjust doses to ensure safe use.

5. Boceprevir: It is generally not recommended to use doxazosin with boceprevir. Your doctor may consider alternative treatments or adjust your medication regimen.

It is crucial to follow your doctor's guidance and report any new symptoms or concerns promptly.