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Here is crucial safety and warning information for using this medication. Please read these details thoroughly and discuss any concerns with your healthcare provider.

• Heart Health Concerns: Cevimeline (Evoxac) may impact the electrical activity of the heart, potentially altering heart rate and rhythm. If you have experienced chest pain or a heart attack, inform your doctor as these changes might be challenging for your heart to manage.

• Respiratory Considerations: This medication can impede airflow, hinder lung muscle relaxation, and increase mucus production, making breathing more difficult. It is essential to discuss any pre-existing lung conditions, such as asthma or chronic obstructive pulmonary disease (COPD), with your healthcare provider before starting treatment.

• Vision Impairments: Cevimeline (Evoxac) may affect eye muscles, leading to blurred vision, particularly in low-light conditions. Avoid driving or operating machinery until you understand how this medication impacts your vision.

• Gallstones and Kidney Stones: If you have a history of gallstones or kidney stones, inform your healthcare provider. Cevimeline can influence muscle contractions, potentially causing blockages or swelling in the gallbladder duct and facilitating the formation of kidney stones.

Contraindications: There are specific conditions where the use of this medication is not advised due to significant health risks. If any of the following apply to you, consult your healthcare provider:

• Presence of uncontrolled asthma.
• Conditions where pupil narrowing could be harmful, such as acute iritis or narrow-angle (angle closure) glaucoma.

Common side effects:

• Sweating
• Headaches
• Nausea
• Sinus inflammation
• Runny nose
• Diarrhea
• Stomach discomfort
• Pain
• Urinary tract infections
• Coughing
• Vomiting

Less common but important to monitor:

• Back pain
• Joint pain
• Rashes
• Dizziness
• Changes in vision
• Fatigue
• Anxiety
• Flushing
• Trouble sleeping
• Frequent urination

Serious side effects:

• Excessive sweating
• Breathing problems
• Significant headaches
• Visual changes
• Increased tear production
• Nausea
• Vomiting
• Diarrhea
• Changes in heart rate
• Confusion
• Tremors
• Severe allergic reactions
• Rash
• Itching
• Swelling (particularly of the face, tongue, or throat)
• Severe dizziness
• Trouble breathing

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• beta blockers (such as metoprolol, atenolol)
• Cimetidine
• Amiodarone
• Ritonavir
• Fluoxetine