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This information outlines important safety and warning details regarding the use of pilocarpine (Salagen). Please read carefully and discuss any concerns with your healthcare provider.

• Potential Worsening of Medical Conditions: Pilocarpine (Salagen) may aggravate existing health issues. Inform your healthcare provider of your complete medical history before beginning treatment. Conditions that may be affected include problems with brain function, mental health, eyesight, respiratory issues (such as asthma or COPD), cardiovascular conditions (like high blood pressure or heart rate abnormalities), gallbladder, liver, and kidney issues.

• Vision Changes: This medication may cause blurred vision and difficulties with depth perception, particularly in low-light situations. Avoid activities requiring full concentration, such as driving, until you understand how pilocarpine (Salagen) affects you. Exercise caution when driving at night or in dim lighting, especially when starting the medication or adjusting the dosage. Report any persistent vision problems to your provider.

• Overdose Risks: Taking an excessive dose of pilocarpine (Salagen) can intensify side effects, which may include visual disturbances, excessive tearing, increased sweating, stomach upset, tremors, headache, respiratory difficulties, abnormal blood pressure or heart rhythms, and confusion. Discontinue use and consult your healthcare provider if these symptoms occur, as a dosage adjustment or alternative medication may be necessary.

• Contraindications: Avoid using pilocarpine (Salagen) if you have uncontrolled asthma or conditions where pupil constriction is dangerous, such as acute iritis or narrow-angle glaucoma. Always consult your healthcare provider if these contraindications apply to you before starting the medication.

Common side effects:

• Temporary irritation
• Burning of the eye
• Stinging of the eye
• Blurred vision
• Poor vision in dim light
• Headaches
• Brow aches
• Sweating
• Nausea
• Chills
• Runny nose
• Flushing
• Frequent urination
• Weakness
• Dizziness

Serious side effects:

• Eye pain
• Changes in vision
• Fast heart rate
• Muscle pain
• Itching
• Rash
• Swelling of the face, tongue, or throat
• Severe dizziness
• Trouble breathing

When taking pilocarpine hydrochloride, it's important to be aware of potential interactions with other medications:

• Beta-Blockers: These medications, often prescribed for heart conditions, can interact with pilocarpine, potentially leading to heart rhythm disturbances. If you're using beta-blockers, your doctor may need to monitor your heart function closely.

• Anticholinergic Drugs: Medications like atropine or inhaled Ipratropium, which have anticholinergic effects, may have reduced effectiveness when taken with pilocarpine. This is because pilocarpine can counteract their actions.

• Parasympathomimetic Agents: Combining pilocarpine with other drugs that stimulate the parasympathetic nervous system can amplify side effects. This includes medications such as bethanechol.

Always inform your healthcare provider about all the medications you're currently taking, including over-the-counter drugs and supplements, to ensure safe and effective use of pilocarpine.