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This medication can decrease your body's ability to fight an infection. This effect can lead to very serious (possibly fatal) infections (such as fungal infections, bacterial infections including tuberculosis). You should have a tuberculosis (TB) skin test before and during treatment with this medication. Also tell your doctor your medical history, especially of past/recent/current infections. You should also tell your doctor if you have lived or traveled in areas where certain fungal infections (such as coccidioidomycosis, histoplasmosis) are common or if you have been near someone with tuberculosis. Tell your doctor right away if you develop signs of an infection while using this drug, such as sore throat or cough that doesn't go away, fever, chills, night sweats, painful/frequent urination, unusual vaginal discharge, white patches in the mouth (oral thrush). If you are diagnosed with TB, you must first be treated for it before you start certolizumab to prevent a serious TB infection. Though it is very unlikely to happen, there is a risk (especially in children/teens/young adults) of developing cancer (such as lymphoma, skin) due to this medication or due to your medical condition. Discuss the risks and benefits of treatment with your doctor. Tell your doctor right away if you develop symptoms such as fever that doesn't go away, unusual lumps/growths, skin changes, swollen lymph nodes, swollen or painful abdomen, unexplained weight loss, or night sweats.

Some products that may interact with this drug include: abatacept, anakinra, other drugs that weaken the immune system (such as azathioprine, cancer chemotherapy, cyclosporine). This medication may interfere with certain lab tests (such as aPTT tests), possibly causing false test results. Make sure lab personnel and all your doctors know you use this drug.