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This medication, Cimzia (certolizumab), is associated with certain risks and precautions that are critical for your safety. It is essential to understand these before starting treatment. Please review the following safety information carefully and discuss any concerns with your healthcare provider:

• Risk of Serious Infections: Cimzia can impair your immune system, making you more susceptible to serious infections, which can be life-threatening. This risk increases if you have current, chronic, or recurring infections, are over 65 years old, have conditions that predispose you to infections, or are taking other immunosuppressive medications like steroids or methotrexate. A TB skin test is recommended before and during treatment. Inform your doctor if you have been in areas with high TB or fungal infection rates. Report symptoms like persistent sore throat, fever, night sweats, or any signs of infection immediately.

• Potential for Cancer: There is a heightened risk of developing cancer, such as lymphoma, leukemia, or skin cancer, particularly in individuals under 18, those on other immunosuppressants like mercaptopurine or azathioprine, those with a history of cancer, or those with rheumatoid arthritis. Regular monitoring through blood tests and physical exams may be necessary. Contact your healthcare provider if you notice symptoms such as swollen lymph nodes, unexplained fatigue, weight loss, or skin lumps.

• Heart Failure Concerns: Some individuals may experience new or worsening heart failure while using Cimzia. Notify your provider of any heart failure history. Seek medical attention if you experience symptoms like shortness of breath, leg swelling, irregular heartbeat, or persistent fatigue.

• Nervous System Issues: Although rare, Cimzia can be linked to new or worsening neurological problems, including seizures and multiple sclerosis. If you have a history of neurological issues, inform your doctor. Report symptoms such as dizziness, muscle weakness, or changes in vision or balance.

• Low Blood Cell Counts: Cimzia may lead to decreased blood cell counts, increasing the risk of infections, bleeding, and anemia. If you experience signs like fever, fatigue, or unusual bleeding, contact your healthcare provider immediately.

• Allergic Reactions: Rare allergic reactions to Cimzia can occur, including rash, hives, difficulty breathing, or swelling of the face or lips. Immediate medical assistance is necessary if an allergic reaction occurs.

In case of an overdose or any severe reaction, seek emergency medical attention promptly. Always inform your healthcare provider of your complete medical history and any medications you are currently taking to ensure safe and effective use of Cimzia.

Certolizumab can cause a variety of side effects, which can be categorized as common, less common, and serious. Common side effects include symptoms such as cough, sore throat, stuffy or runny nose, and joint pain. These are generally mild and should not cause concern unless they persist or worsen. Other common effects may include upper respiratory infections, rashes, and urinary tract infections. If these symptoms are persistent, consulting a healthcare provider is advisable.

Some patients may experience other side effects such as headaches, pain, swelling, or redness at the injection site, fever, and hives. While these are less common, they should still be monitored. Infections such as herpes can also occur and should be reported to a healthcare provider if symptoms appear.

More serious side effects are rare but require immediate medical attention. These include symptoms of serious infections like fever, difficulty breathing, and chills. Heart failure symptoms such as shortness of breath, swelling in the legs, and irregular heartbeat are also serious concerns. Other severe side effects may signal possible cancer, such as unexplained weight loss, fatigue, or swollen lymph nodes. Additionally, severe allergic reactions, which may present as hives, severe dizziness, or trouble breathing, require urgent care.

A very serious, albeit rare, side effect is possible liver damage, especially in those exposed to hepatitis B. Symptoms like persistent nausea, stomach pain, dark urine, and yellowing of the skin or eyes should prompt immediate medical evaluation. It is important for individuals to seek medical advice if they encounter any unusual symptoms while using certolizumab.