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This document provides essential safety information regarding the use of clindamycin. Please read carefully and consult your healthcare provider if you have any questions or concerns.

• Severe Allergic Reactions: Clindamycin may cause serious allergic reactions, including anaphylaxis or swelling of the airways. If you experience symptoms such as hives, rash, swelling of the lips or tongue, or difficulty breathing, seek immediate medical attention. Clindamycin should not be used if you have a known allergy to clindamycin or lincosamide antibiotics.

• Severe Diarrhea: Antibiotics like clindamycin can lead to diarrhea by disrupting the balance of bacteria in your gut. In rare cases, this may result in an infection by Clostridioides difficile (C. diff), which is highly contagious and can cause severe dehydration. Individuals with bowel conditions such as Crohn's disease or ulcerative colitis are at increased risk. Inform your healthcare provider if you have a history of bowel problems or severe diarrhea following antibiotic use.

• Damage to Condoms and Diaphragms: Clindamycin can weaken condoms and vaginal diaphragms, increasing the risk of unintended pregnancy and sexually transmitted diseases (STDs). Consult your healthcare provider or pharmacist about alternative barrier methods during treatment. It is generally advised to avoid vaginal intercourse until the infection is resolved to prevent further irritation.

• Vaginal Yeast Infections: The use of clindamycin may increase the likelihood of developing vaginal yeast infections due to its effect on beneficial bacteria. Symptoms of a yeast infection include redness, pain, burning, or thick, white discharge. Contact your healthcare provider if you notice these symptoms, as treatment may be necessary.

Contraindications:

• Do not use clindamycin if you have an allergy to clindamycin or lincosamide antibiotics.
• Avoid use if you have a history of specific stomach or intestinal conditions, such as regional enteritis, ulcerative colitis, or antibiotic-associated colitis.

If any of these conditions apply to you, it is crucial to consult your healthcare provider before starting clindamycin.

When using this medication, some common side effects may occur, though they are generally mild. These include headache, back pain, and mild stomach upset. Some individuals might also experience discomfort, inflammation, or pain in the vulva and vagina, which could potentially lead to a vaginal yeast infection. If these symptoms persist or worsen, it is advisable to consult with your healthcare provider to ensure proper management and care.

Other potential side effects, which are less frequent but have been reported, include constipation, irregular menstrual cycles, urinary tract infections, and skin yeast infections. While these are generally manageable, it is important to monitor your symptoms and seek advice from a healthcare professional if needed.

In rare cases, the medication can cause more serious side effects that require immediate medical attention. These include severe allergic reactions characterized by hives, rash, swelling of the lips or tongue, and difficulty breathing. Additionally, a serious intestinal condition may occur, marked by severe diarrhea, stomach cramps, blood or mucus in your stool, and fever. If you experience any of these symptoms, it is crucial to seek urgent medical care. Avoid using anti-diarrhea or opioid products, as they may exacerbate the condition.

While this is not an exhaustive list of potential side effects, it highlights the most significant ones. Always consult your healthcare provider if you notice any other unexpected symptoms to ensure your safety and well-being.