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IGF-1 Deficiency

IGF-1 deficiency is a rare condition where the body lacks the hormone insulin-like growth factor-1. It can be caused by genetic factors or medical conditions. Symptoms vary but may include impaired growth, reduced muscle mass, and fatigue. Diagnosis involves blood tests and imaging studies. Treatment involves synthetic IGF-1 injections or growth hormone therapy. Early intervention is important, and a healthy lifestyle is recommended for optimal outcomes. Consult a healthcare professional for advice and treatment.

Best medications for IGF-1 Deficiency

Drug NameClassRouteStandard DosagePrice
IncrelexRecombinant IGF-1Subcutaneous40 MG/4MLfrom$5930.81


IGF-1 deficiency, also known as insulin-like growth factor-1 deficiency, is a rare medical condition characterized by a deficiency of the hormone insulin-like growth factor-1 (IGF-1) in the body. IGF-1 is an important hormone that plays a crucial role in growth and development during childhood and adolescence. It is produced by the liver in response to stimulation by human growth hormone (HGH), which is secreted by the pituitary gland. Inadequate production or utilization of IGF-1 can have various effects on the body and can lead to several health problems.


IGF-1 deficiency can be caused by a variety of factors. One common cause is a genetic mutation or abnormality that affects the body's ability to produce or process the hormone. Certain medical conditions, such as growth hormone deficiency or malnutrition, can also contribute to IGF-1 deficiency. In some cases, the exact cause may be unknown.


The symptoms of IGF-1 deficiency can vary depending on the age of onset and severity of the condition. In children, one of the primary signs is impaired growth, resulting in short stature and delayed puberty. Adults with IGF-1 deficiency may experience a decrease in muscle mass, increased body fat, reduced bone density, and changes in cognitive function. Other symptoms may include fatigue, decreased stamina, and feelings of depression or anxiety.


Diagnosing IGF-1 deficiency begins with a thorough evaluation of the patient's medical history and a physical examination. Blood tests are then conducted to measure the levels of IGF-1, growth hormone, and other related hormones. Imaging studies, such as X-rays or bone density scans, may also be performed to assess bone health. Additionally, genetic testing may be recommended to identify any underlying genetic causes of the condition.


The primary treatment for IGF-1 deficiency is the administration of synthetic IGF-1 through injections. This helps to supplement the low levels of the hormone in the body, promoting growth and development in children and improving body composition in adults. The dosage and frequency of the injections are determined by the individual's specific needs and are closely monitored by a healthcare provider. In some cases, growth hormone therapy may also be prescribed to stimulate the production of IGF-1.


With appropriate treatment and management, individuals with IGF-1 deficiency can lead healthy and fulfilling lives. Early diagnosis and intervention are crucial for optimizing growth and development in children. Regular monitoring of hormone levels and close follow-up with healthcare professionals are important to ensure a successful treatment outcome. It is essential for patients with IGF-1 deficiency to maintain a healthy lifestyle, including proper nutrition and exercise, to support overall growth and well-being. Please note that this article should not be considered medical advice. It is always recommended to consult with a healthcare professional for proper diagnosis and guidance regarding the treatment of IGF-1 deficiency or any other medical condition.