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The safety and warning information for Increlex (mecasermin) is crucial for understanding the potential risks and precautions associated with its use. Please review the following points carefully and discuss any concerns with your healthcare provider.

• Low Blood Sugar (Hypoglycemia): Increlex (mecasermin) may cause severe low blood sugar, which can be life-threatening. This risk is heightened when beginning treatment or when doses are frequently adjusted. Factors increasing this risk include young age, changes in diet or exercise, concurrent use of other blood sugar-lowering medications, alterations in Increlex dosage, overdosing, not eating within 20 minutes of administration, and engaging in high-risk activities within 2 to 3 hours post-dose.

• Allergic Reactions: Some individuals may experience allergic reactions to Increlex (mecasermin), which can manifest as widespread hives, facial or oral swelling, breathing difficulties, or anaphylaxis. Seek immediate medical attention if such reactions occur.

• Increased Intracranial Pressure: There have been reports of increased pressure in the brain in children taking Increlex (mecasermin). Symptoms can include vision changes, headaches, nausea, vomiting, and papilledema (swelling of the optic disc).

• Enlarged Lymph Tissues: Treatment may cause enlargement of tonsils and adenoids, leading to sleep apnea, snoring, or ear fluid buildup. Regular follow-ups will monitor the size of these tissues.

• Hip Problems: Increlex (mecasermin) can lead to a condition known as slipped capital femoral epiphysis, especially in rapidly growing children, which may cause a limp or hip/knee pain. Contact your healthcare provider if these symptoms arise.

• Worsening Scoliosis: If your child has scoliosis, be aware that Increlex (mecasermin) may exacerbate the condition due to accelerated growth. Watch for signs such as uneven shoulders, waist, or body leaning, which should be evaluated during follow-up visits.

• Cancer Risk: There is a potential risk of developing cancer while using Increlex (mecasermin), especially at higher doses or when other risk factors are present. Children with a current or past history of cancer should not use this medication. Discuss cancer risks with your healthcare provider.

Contraindications: Do not use Increlex (mecasermin) if there is closure of the growth plates or if there is a current or past history of cancer, as these conditions pose significant health risks. Always consult your healthcare provider if any of these conditions apply.

When taking this medication, some individuals may experience common side effects. These usually include low blood sugar and swollen tonsils. While these effects are generally mild, it is advisable to consult a healthcare provider if they persist or worsen to ensure proper management and reassurance.

There are additional side effects that have been reported by users of this medication. These can include bruising or thickening of the skin at the injection site, headaches, dizziness, uncontrolled muscle spasms, vomiting, joint pain, and pain in the arm or leg. Additionally, some individuals have reported ear-related issues such as infections, pain, fluid buildup, and snoring. If any of these occur, especially if bothersome, consulting with a healthcare provider can be beneficial.

Rare but serious side effects demand immediate medical attention due to their severity. These include a noticeable thickening of the skin around the face and other reactions at the injection site like irritation, redness, pain, or rash. If you experience these, seeking urgent medical care is crucial to address these concerns promptly.