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Polycythemia Vera

Polycythemia Vera is a rare blood disorder that causes an overproduction of red blood cells. It primarily affects older adults, and its exact cause is unknown. Symptoms include fatigue, headaches, and itching skin. Diagnosis involves medical history, blood tests, and genetic testing. While there is no cure, treatments aim to manage symptoms and reduce complications. Phlebotomy, medications, and supportive care are common treatment options. Regular monitoring and follow-up with healthcare professionals are essential.

Best medications for Polycythemia Vera

Drug NameClassRouteStandard DosagePrice
VonjoKinase InhibitorsOral100 MGfrom$6452.50
BesremiInterferon AlphasSubcutaneous500 MCG/MLfrom$8487.09


Polycythemia Vera is a rare blood disorder characterized by the overproduction of red blood cells in the bone marrow. It falls under the category of myeloproliferative neoplasms, a group of disorders that result in the excessive production of blood cells. Polycythemia Vera is a chronic condition that primarily affects older adults, with a slightly higher incidence in males. Although the exact cause of this disorder is unknown, it is thought to be related to a genetic mutation.


The symptoms of Polycythemia Vera are often vague and nonspecific, making it challenging to diagnose early. The most common symptoms include:

  • Fatigue and weakness

  • Headaches, dizziness, or lightheadedness

  • Shortness of breath, especially during physical activity

  • Excessive sweating, particularly at night

  • Blurred vision or changes in vision

  • Itchy skin, usually after a warm bath or shower

  • Redness, warmth, or tingling sensation in hands and feet

In some cases, individuals with Polycythemia Vera may experience complications such as blood clots, which can lead to serious conditions like stroke or heart attack.


Diagnosing Polycythemia Vera requires a thorough evaluation by a healthcare professional. The process typically involves:

  • Medical history and physical examination

  • Complete blood count (CBC) to assess the levels of red blood cells, white blood cells, and platelets

  • Measurement of hematocrit, which determines the volume of red blood cells in the blood

  • Genetic testing to identify the JAK2 mutation, which is present in the majority of people with Polycythemia Vera

  • Additional tests, such as bone marrow biopsy, to confirm the diagnosis and rule out other possible conditions


While there is currently no cure for Polycythemia Vera, treatments aim to manage symptoms, reduce the risk of complications, and prevent the progression of the disease. Common treatment options include:

  • Phlebotomy: The removal of blood from the body to decrease the number of red blood cells

  • Medications: Blood thinners to reduce the risk of blood clots or other drugs to suppress the production of blood cells

  • Low-dose aspirin: Used to prevent the formation of blood clots

  • Supportive care: Adequate hydration, regular exercise, and avoiding exposure to extreme temperatures

Ongoing monitoring and follow-up with a healthcare professional are essential for individuals with Polycythemia Vera to ensure treatment effectiveness and address any complications that may arise.


Polycythemia Vera is a chronic blood disorder characterized by the overproduction of red blood cells. Although it cannot be cured, proper management and treatment can significantly improve the quality of life for individuals with this condition. Early diagnosis, regular monitoring, and adherence to medical recommendations are crucial in preventing complications and maintaining overall health.