Jakafi

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Ruxolitinib, marketed as Jakafi, is a medication used to treat specific blood disorders and conditions, including myelofibrosis (MF) and polycythemia vera (PV) in adults, as well as graft-versus-host disease (GVHD) in individuals aged 12 and older. As a JAK inhibitor, Ruxolitinib functions by blocking JAK proteins, which are involved in cell growth and immune system responses. Although it is not a cure, Ruxolitinib helps alleviate symptoms such as abdominal discomfort, rib pain, early satiety, night sweats, itching, and bone or muscle pain associated with these disorders. It is particularly used for patients who cannot tolerate or have previously tried other medications like hydroxyurea for PV or corticosteroids for GVHD. Administered orally twice daily, common side effects may include low blood cell counts, infections, and fatigue. Always consult with a healthcare provider for advice tailored to your medical needs before starting this treatment.
Our Jakafi coupons are free to use. You can print the coupon, email it to yourself, or receive the Jakafi coupon via text message. To get your free discount, show the pharmacist your Jakafi savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The Jakafi prices will update based on your prescription needs. Above our Jakafi coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the Jakafi savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.

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10MG, Jakafi (30 Tablets)

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Rite Aid

$8755.81

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$9126.40

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Rite Aid

$8755.81

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Jakafi dosage forms

The average cost for 30 Tablets of Jakafi at 5MG is $8872.15 with a free coupon. This is 27.95% off the average retail price of $31747.39
DosageQuantityPrice fromPer unit
5MG30 Tablets$8872.15$295.74
15MG30 Tablets$8872.15$295.74
20MG30 Tablets$8872.15$295.74
10MG30 Tablets$8872.15$295.74
25MG30 Tablets$8872.15$295.74

Jakafi Warnings

Here are essential safety and warning details for Jakafi (ruxolitinib) that you should carefully consider. Consult your healthcare provider for advice tailored to your situation.

  • Low Blood Cell Counts: The use of Jakafi can lead to a decrease in red and white blood cells, as well as platelets. A reduction in red blood cells may cause fatigue, while a lower count of white blood cells can increase the risk of infections. A decreased platelet count may result in difficulty stopping bleeding.

  • Increased Infection Risk: Patients taking Jakafi have a higher susceptibility to bacterial, fungal, and viral infections. Serious conditions like tuberculosis (TB) may arise, especially in those with a history of TB, herpes simplex infection, or who have traveled to areas with high TB prevalence.

  • Effects When Discontinuing Jakafi: Stopping Jakafi treatment, particularly for myelofibrosis or polycythemia vera, might lead to the recurrence of previous symptoms and could cause fever, breathing difficulties, low blood pressure, or serious conditions like disseminated intravascular coagulation (DIC) and organ failure.

  • Skin Cancer Risk: There is a possibility of developing new skin cancers, such as basal cell carcinoma, squamous cell carcinoma, or Merkel cell carcinoma. Regular skin examinations are advised, and any unusual skin changes should be reported to an oncologist or dermatologist promptly.

  • Potential Heart Problems and Stroke: Although Jakafi is not approved for rheumatoid arthritis, similar JAK inhibitors have been linked to serious heart issues and strokes, particularly in patients with existing risk factors or those who are current or former smokers.

  • Blood Clot Risk: Similar JAK inhibitors used for rheumatoid arthritis have been associated with blood clots like deep vein thrombosis (DVT) and pulmonary embolism (PE). Jakafi is not approved for rheumatoid arthritis treatment.

  • New Cancer Risk: There is a potential risk for new cancers, such as lymphoma, especially in current or past smokers, based on observations from other JAK inhibitors used for rheumatoid arthritis. Discuss any concerns with your oncology or hematology specialist.

Please note that there are no specific contraindications listed for Jakafi. Always seek personalized medical advice from your healthcare provider.

Jakafi Side Effects

When taking this medication, you may encounter some common side effects that are generally mild and manageable. These include dizziness, diarrhea, headache, gas, weight gain, and muscle, bone, or joint pain. Some individuals might also experience infections like urinary tract or viral infections, anemia, low white blood cells, low platelets, and increased cholesterol or liver enzyme levels. If these effects persist or worsen, it's advisable to consult your healthcare provider to ensure proper management.

More serious side effects, although rare, demand urgent medical attention. These include symptoms of low white blood cells and infections, such as fever, chills, severe tiredness, body aches, or trouble breathing. Low platelet levels can lead to unexpected bleeding or bruising, nosebleeds, and blood in urine or stool. Serious heart issues, strokes, and blood clots are critical side effects to be aware of. These can manifest as chest pain, chest tightness, sudden numbness or weakness on one side of the body, severe headaches, difficulty breathing, speaking, or walking, and swelling in the limbs. Immediate medical care is crucial if any of these severe symptoms are observed.

Additionally, there is a very rare but significant risk of a brain infection called progressive multifocal leukoencephalopathy (PML), which may present as confusion, difficulty concentrating, seizures, or vision changes. A serious allergic reaction, though uncommon, can also occur, indicated by a rash, severe dizziness, trouble breathing, or swelling of the face, tongue, or throat. If any unusual symptoms arise, contacting your healthcare provider promptly is important to ensure safety and well-being.

Jakafi Interactions

Jakafi (ruxolitinib) has the potential to interact with other medications, particularly those that can weaken the immune system or raise the risk of infection, such as natalizumab and rituximab. Additionally, it is important to inform your healthcare provider about all medications and supplements you are taking, including prescription drugs, over-the-counter medicines, vitamins, and herbal products. There are several medications that are generally not recommended to be used with Jakafi, but in some situations, co-administration might be necessary. If both are prescribed, your doctor may adjust the dosage or frequency. These medications include Abatacept, Boceprevir, Clarithromycin, Cobicistat, Conivaptan, Fluconazole, Idelalisib, Indinavir, Itraconazole, Ketoconazole, Lopinavir, Nefazodone, Nelfinavir, Posaconazole, Ritonavir, Saquinavir, Telaprevir, Telithromycin, and Voriconazole. Always consult your doctor or pharmacist for guidance tailored to your specific situation.
Jakafi FAQs
What does the drug Jakafi do?

Jakafi is a medication used to treat certain types of bone marrow disorders, such as myelofibrosis and polycythemia vera. It works by inhibiting specific enzymes known as Janus kinases (JAKs), which are involved in the signaling pathways that regulate blood cell production and immune function. By targeting these enzymes, Jakafi helps to reduce symptoms and control the overproduction of blood cells associated with these conditions.

Jakafi (ruxolitinib) is not considered traditional chemotherapy. It is classified as a targeted therapy, specifically a Janus kinase (JAK) inhibitor, used to treat certain types of blood disorders.

The life expectancy of patients taking Jakafi (ruxolitinib) can vary significantly depending on the underlying condition being treated, the stage of the disease, and individual patient factors. Jakafi is commonly used to treat conditions like myelofibrosis and polycythemia vera, which can have different prognoses. While Jakafi can help manage symptoms and improve quality of life, it is not a cure. Patients should discuss their specific prognosis and treatment outcomes with their healthcare provider, who can provide information tailored to their individual health status.

Jakafi is expensive due to several factors, including the costs associated with its research and development, clinical trials, and regulatory approval processes. Additionally, it is a specialized medication used to treat rare conditions, which often results in higher pricing due to limited patient populations. The costs of manufacturing, marketing, and distribution also contribute to its price. Furthermore, the pricing strategy may reflect the value it provides in terms of efficacy and the lack of alternative treatments for the conditions it addresses.

The chemotherapy pill commonly used for polycythemia vera is hydroxyurea. It helps to reduce the number of red blood cells and control symptoms associated with the condition.

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