HomeConditionsRestless Leg Syndrome

Restless Leg Syndrome

Restless Leg Syndrome (RLS), also known as Willis-Ekbom Disease, is a neurological disorder causing an uncontrollable urge to move the legs, especially at night. It can disrupt sleep and is often linked to dopamine imbalance, iron deficiency, pregnancy, or certain medications. Symptoms include leg sensations and the urge to move, worsened by rest. Diagnosis involves evaluation and ruling out other conditions, and treatment includes lifestyle changes and medications. While there is no cure, proper management can provide relief and

Best medications for Restless Leg Syndrome

Drug NameClassRouteStandard DosagePrice
rOPINIRole HClDopamine AgonistsOral3, 0.25, 6, 1, 8, 5, 12, 4, 0.5, 2 MGfrom$9.00
MirapexDopamine AgonistsOral1.5, 3, 0.375, 2.25, 0.25, 0.125, 4.5, 1, 0.5, 3.75, 0.75 MGfrom$9.00
Mirapex ERDopamine AgonistsOral1.5, 3, 0.375, 2.25, 4.5, 3.75, 0.75 MGfrom$70.91
NeuproDopamine AgonistsTransdermal3, 6, 1, 8, 4, 2 MG/24HRfrom$815.35
HorizantAnti-epilepticsOral600, 300 MGfrom$503.39


Restless Leg Syndrome (RLS), also known as Willis-Ekbom Disease, is a neurological disorder that affects the nervous system, leading to an uncontrollable urge to move the legs. This condition often occurs in the evening or at night, making it especially disruptive to sleep. RLS can significantly impact a person's quality of life, making it essential to seek medical attention for proper diagnosis and treatment.


The exact cause of RLS is unknown, but several factors have been associated with the development of this condition. The primary cause is believed to be an imbalance of dopamine, a chemical messenger in the brain that helps regulate muscle movement. In some cases, RLS may also be linked to iron deficiency, kidney disease, pregnancy, or certain medications.


The hallmark symptom of RLS is an intense urge to move the legs, often accompanied by uncomfortable sensations such as crawling, tingling, or pins and needles. This urge worsens during periods of rest or inactivity and is temporarily relieved by movement. Symptoms typically occur in the evening or at night, leading to difficulty falling or staying asleep.


Diagnosing RLS involves a thorough evaluation of the patient's medical history and a physical examination. There are no specific tests to diagnose RLS, but healthcare professionals may use certain criteria, such as the presence of diagnostic symptoms and the pattern of symptoms over time, to make an accurate diagnosis. In some cases, additional blood tests may be ordered to rule out other underlying conditions.


While there is no cure for RLS, several treatment options can help manage the symptoms and improve the quality of life for individuals with this condition. Lifestyle changes, including regular exercise, avoiding caffeine and alcohol, and implementing a regular sleep routine, can be beneficial. Medications such as dopamine agonists, opioids, anticonvulsants, and sleep medications may also be prescribed to relieve symptoms.


Restless Leg Syndrome is a chronic condition that requires long-term management. With proper diagnosis and treatment, most individuals with RLS can experience significant relief from their symptoms. It is important to work closely with a healthcare professional to determine the most appropriate treatment plan based on individual needs and goals.

If you suspect you may have Restless Leg Syndrome, it is recommended to consult with a healthcare provider for a proper evaluation and to discuss the available treatment options.