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Below are important safety warnings concerning the use of ropinirole. It is essential to understand these risks and precautions, and discuss any concerns with your healthcare provider.

• Extreme Sleepiness: Ropinirole may induce severe drowsiness, occasionally leading to sudden sleep episodes. The risk increases when combined with other sedatives like benzodiazepines, muscle relaxants, and sleep aids, or with alcohol consumption. Avoid driving or engaging in activities that require full concentration until you know how ropinirole affects you. Consult your healthcare provider if you experience excessive drowsiness or sudden sleep onset.

• Blood Pressure Changes and Fall Risk: This medication can cause fluctuations in blood pressure, potentially resulting in dizziness, balance issues, or falls, especially upon standing. Rise slowly from sitting or lying positions and hold onto stable surfaces. Seek medical advice if you experience lightheadedness, fainting, or falls. Individuals with low blood pressure or those taking antihypertensives should exercise caution.

• Compulsive Behaviors: Ropinirole may provoke uncontrollable urges, such as gambling, heightened sexual desires, shopping, or overeating. Notify your healthcare provider if you or those around you notice these behaviors, as medication adjustments may be necessary.

• Hallucinations and Behavior Changes: Some users may experience hallucinations, confusion, paranoia, or violent behavior. Those with a history of mental health issues, particularly individuals over 65 or with advanced Parkinson's disease, should be cautious. Immediate medical consultation is advised if such symptoms occur.

• Uncontrolled Body Movements: Ropinirole might cause or worsen involuntary movements like eye-twitching or lip-smacking, particularly in patients using levodopa-containing Parkinson's medications. Report any such symptoms to your healthcare provider, who may adjust your dosage.

• Worsening of Restless Legs Syndrome (RLS): The immediate-release formulation can exacerbate RLS symptoms, either intensifying them or causing them to spread to other body parts. Symptoms may also arise earlier in the day or return in the early morning. Discuss any symptom changes with your provider to consider dose adjustments.

Please ensure you understand these considerations and consult your healthcare provider for personalized advice and management.

Common side effects:

• nausea
• dizziness
• sleepiness
• weakness
• vomiting
• indigestion

Less common but important to monitor:

• faintness
• viral infection

Serious side effects:

• stomach pain
• confusion
• anxiety
• excessive sweating
• dry mouth
• sudden drops in blood pressure
• falling asleep during daily activities
• severe allergic reaction (rash, itching, swelling, severe dizziness, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Sulpiride

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Haloperidol
• Metoclopramide
• Warfarin

Interactions with low risk that usually do not require a change in therapy:

• Ciprofloxacin
• Kava
• Cimetidine
• Fluvoxamine
• Mexiletine
• Omeprazole
• Codeine
• Hydrocodone
• Alcohol
• Cannabis
• Alprazolam
• Lorazepam
• Zolpidem
• Carisoprodol
• Cyclobenzaprine
• Cetirizine
• Diphenhydramine