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Ibuprofen is a nonsteroidal anti-inflammatory drug that may, in rare instances, increase the risk of heart attack or stroke. This risk is present throughout the duration of use but is heightened with long-term consumption. Older adults and individuals with heart disease, or risk factors for heart disease, are more susceptible. Such risk factors include smoking, a family history of heart disease, high blood pressure, and diabetes. It is crucial not to use this medication immediately before or after undergoing heart bypass surgery (CABG).

Additionally, ibuprofen can occasionally lead to severe, potentially fatal bleeding in the stomach or intestines, which may occur unexpectedly. The likelihood of this happening increases with age.

If you experience any of the following rare but serious side effects, discontinue use of ibuprofen and seek medical attention immediately:

• Persistent stomach or abdominal pain
• Black or tarry stools
• Vomit resembling coffee grounds
• Pain in the chest, jaw, or left arm
• Shortness of breath
• Unusual sweating
• Confusion
• Weakness on one side of the body
• Difficulty speaking
• Sudden changes in vision

It is advisable to discuss with your healthcare provider the potential benefits and risks associated with taking ibuprofen to determine if it is suitable for you.

This medication may cause some mild side effects such as upset stomach, nausea, vomiting, headache, diarrhea, constipation, dizziness, or drowsiness. These are generally not serious and often resolve as your body adjusts. However, if any of these persist or worsen, it is important to inform your healthcare provider.

In some cases, this medication can lead to an increase in blood pressure, so it's advisable to monitor your blood pressure regularly. More concerning side effects, though less common, include easy bruising or bleeding, changes in hearing like ringing in the ears, mood or mental changes, unexplained stiff neck, signs of kidney issues (such as changes in urine output), vision changes, and symptoms of heart failure, such as swollen ankles, unusual tiredness, or sudden weight gain. If you experience any of these, seek medical attention promptly.

There is a rare risk of serious liver damage, which requires immediate medical intervention. Symptoms to watch for include persistent nausea or vomiting, loss of appetite, dark urine, stomach or abdominal pain, and yellowing of the eyes or skin.

Although a severe allergic reaction is rare, it is crucial to get emergency medical help if you have symptoms like fever, swollen lymph nodes, rash, itching or swelling particularly of the face, tongue, or throat, severe dizziness, or difficulty breathing.

This is not an exhaustive list of side effects, so if you notice any other unusual symptoms, contact your healthcare provider.

This medication can interact with several other drugs, potentially affecting your health. Be cautious if you're also taking Aliskiren, ACE inhibitors like Captopril or Lisinopril, angiotensin II receptor blockers such as Losartan or Valsartan, Cidofovir, corticosteroids like Prednisone, Lithium, or diuretics like Furosemide. These combinations may cause unwanted effects.

Additionally, this drug might increase bleeding risks if combined with other medications that thin the blood. This includes anti-platelet drugs like Clopidogrel and blood thinners such as Dabigatran, Enoxaparin, or Warfarin.

Check both prescription and non-prescription medication labels carefully, as many contain pain relievers or fever reducers similar to ibuprofen, such as Aspirin and NSAIDs like Celecoxib, Ketorolac, or Naproxen. Using them together may raise the chance of side effects. However, if your doctor has advised you to take low-dose aspirin (usually 81-162 milligrams daily) for heart attack or stroke prevention, continue unless instructed otherwise. Be aware that regular ibuprofen use can reduce aspirin's effectiveness in preventing heart problems. Discuss with your doctor the possibility of using Acetaminophen instead for pain or fever. If ibuprofen is necessary, consult your doctor about taking immediate-release aspirin while using ibuprofen. It's important to maintain a gap of at least 8 hours before or 2 hours after your aspirin dose when taking ibuprofen. Do not alter your aspirin dosage or the way you take any medications without your doctor's approval.