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When using Deferiprone (Ferriprox), it is crucial to be aware of several important safety considerations and potential risks associated with the medication. Below are key points that should be carefully reviewed and discussed with your healthcare provider:

• Low White Blood Cell Count: Deferiprone can significantly reduce your white blood cell count, increasing the risk of severe, possibly fatal infections. Regular blood tests are necessary before starting and during treatment to monitor these levels. Immediate medical attention is required if you experience symptoms of infection, such as a persistent sore throat, fever, chills, or flu-like symptoms. It's important to note that taking other medications that lower white blood cells can increase this risk.

• Elevated Liver Enzymes: The use of Deferiprone may lead to increased liver enzymes, indicative of potential liver damage. Regular blood tests are essential prior to and throughout treatment to monitor liver function. If enzyme levels become too elevated, temporary discontinuation of the medication may be required.

• Low Zinc Levels: Treatment with Deferiprone can result in reduced zinc levels, which may impair infection resistance and cause issues such as hair loss, diarrhea, sexual dysfunction, and loss of appetite. Zinc levels should be monitored regularly, and supplementation may be necessary if levels become too low.

• Risks During Pregnancy: Deferiprone poses a risk to an unborn baby, including the potential for birth defects. Pregnancy must be ruled out before starting the medication, and effective contraception is advised during treatment and for six months after cessation if you are female and capable of becoming pregnant. Males should use contraception if their partner is able to become pregnant, continuing for at least three months after the last dose. Discuss appropriate birth control options with your healthcare provider.

In case of overdose or severe adverse reactions, seek emergency medical assistance immediately. Always follow your healthcare provider's instructions and report any concerning symptoms as soon as they arise.

Common side effects:

• fever
• stomach pain
• bone pain
• headache
• vomiting
• pain in your arms or legs
• sickle cell crisis
• back pain
• abnormal liver function tests
• joint pain
• mouth and throat pain
• cough
• low white blood cell count
• nausea
• diarrhea
• heartburn
• common cold symptoms
• other upper respiratory infections
• general pain
• appetite changes
• weight gain

Serious side effects:

• serious allergic reaction (rash, itching/swelling, severe dizziness, trouble breathing)
• significant drop in white blood cells (fever, sore throat, mouth sores, flu-like symptoms, chills)