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Deferasirox is a medication that requires careful consideration due to its potential risks and necessary precautions. Please review the following safety information and consult with your healthcare provider to ensure safe use.

• Kidney Disease Risks: Deferasirox may rarely lead to severe, potentially fatal kidney issues. This risk is higher for individuals with existing kidney problems, severe blood disorders, or those taking other medications that impact kidney health. Regular monitoring by your healthcare provider will help manage these risks.

• Liver Disease Risks: This medication can cause serious liver problems, particularly in older adults and those with liver conditions such as cirrhosis or organ failure. Children who are severely dehydrated are also at risk. Discuss any liver health concerns with your provider to ensure safe treatment.

• Stomach and Intestinal Bleeding: Deferasirox may cause gastrointestinal bleeding or ulcers, especially in older adults with serious blood conditions. The use of NSAIDs, corticosteroids, bisphosphonates, or blood thinners may increase this risk. Inform your provider of all medications you are taking. Seek medical attention if you experience severe stomach pain, black or tarry stools, or blood in your urine.

• Blood Cell Count Reduction: The medication can reduce blood cell levels, which may be life-threatening, especially in individuals with pre-existing blood disorders. Regular blood tests will be conducted to monitor your condition. Report any signs of bleeding or infection to your provider promptly.

• Excessive Iron Removal: Deferasirox can excessively lower iron levels, affecting kidney and liver function. Your provider will prescribe the minimum effective dose and monitor your iron levels and organ health through regular blood tests, especially if you are receiving blood transfusions or have non-transfusion-dependent thalassemia (NTDT).

• Skin Reactions: Skin rashes and severe reactions can occur. Mild rashes may resolve on their own, but severe cases require immediate medical attention. Stop taking deferasirox if you develop blistering, skin peeling, or high fever.

• Vision and Hearing Issues: Some individuals may experience problems with vision or hearing, with children on higher doses being more susceptible. Regular eye exams and hearing tests are recommended. Notify your provider if you experience hearing loss or vision changes.

• Contraindications: Deferasirox should not be used in cases of moderate or severe kidney disease, high-risk myelodysplastic syndromes, aggressive tumors or late-stage blood cancers, severely low platelet counts, or poor performance status. Consult your healthcare provider if you have any of these conditions.

In the event of an overdose, seek emergency medical assistance immediately. Always follow your healthcare provider’s instructions and keep all scheduled medical and laboratory appointments to ensure your safety while using deferasirox.

When taking this medication, some common side effects you might experience include diarrhea, stomach pain, nausea, vomiting, and skin rash. These are generally mild but consult your healthcare provider if they persist or worsen. Additionally, you might notice higher protein levels in urine, changes in creatinine levels in the blood, or dizziness. Although these effects are often not serious, it’s important to monitor how you feel.

There are other side effects that have been reported, such as sleep problems, anxiety, changes in skin color, and blurry vision. Hearing loss or throat pain may also occur. If any of these side effects become severe, prompt consultation with your healthcare provider is advised.

Some side effects are rare but serious and require immediate medical attention. These include sudden kidney injury, characterized by symptoms like decreased urine output, swelling in the legs, and blood in urine. Liver damage is another severe risk, with signs such as dark urine, yellowing of the skin or eyes, and upper stomach pain. Stomach bleeding, which may present as black or tarry stools, and low blood cell counts, indicated by frequent infections or easy bruising, also require urgent care. Severe skin reactions, including painful rashes or blisters, are rare but serious. If you notice any of these symptoms, seek medical help immediately.

While the risk of a serious allergic reaction is low, symptoms like severe dizziness, trouble breathing, or swelling of the face and throat also require urgent medical attention. Always pay attention to how your body reacts and consult your healthcare provider if you experience any side effects not listed here.

When taking this medication, it's important to be aware of potential interactions with other drugs. Some medications that may interact include fezolinetant, and drugs that increase bleeding risk, such as antiplatelet drugs like clopidogrel, NSAIDs like ibuprofen or naproxen, and anticoagulants like dabigatran and warfarin. Using aspirin with this medication can also raise bleeding risk; however, if your doctor has recommended low-dose aspirin (81-162 mg per day) for heart attack or stroke prevention, continue taking it unless instructed otherwise by your doctor.

This medication may also decrease the effectiveness of hormonal birth control methods, such as pills, patches, or rings, potentially leading to pregnancy. It's advised to discuss alternative contraceptive options with your doctor and report any new spotting or breakthrough bleeding.

Additionally, this medication might slow the elimination of certain drugs from your body, potentially altering their effects. Examples include tovorafenib and others. Always inform your healthcare provider about all medications and supplements you are taking to manage these interactions appropriately.