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Desmopressin usage requires attention due to the potential risk of developing hyponatremia, a condition characterized by low sodium levels in the blood that can be severe or even life-threatening. Below is important safety and warning information related to the use of desmopressin:

• Potential Risks: Hyponatremia is a serious condition that can occur, particularly with excessive fluid intake, use of certain medications (such as diuretics like furosemide or corticosteroids like prednisone), in individuals aged 65 or older, or those with specific medical conditions.

• Precautions: Regular laboratory tests, including urine and sodium blood level tests, are essential before and during treatment with desmopressin. It is crucial to attend all scheduled medical and laboratory appointments.

• Symptoms to Monitor: Be vigilant for signs of low sodium levels, such as nausea, vomiting, headache, muscle weakness or cramps, unusual tiredness or drowsiness, dizziness, restlessness, and mental or mood changes (e.g., confusion or irritability).

• Emergency Actions: Immediate medical attention is necessary if you experience severe side effects, such as seizures or difficulty breathing.

By following these guidelines and maintaining regular communication with your healthcare provider, you can effectively manage your health while using desmopressin.

Common side effects:

• Headache
• Runny or stuffy nose
• Nausea
• Upset stomach
• Facial flushing

Serious side effects:

• Rash
• Itching or swelling, particularly of the face, tongue, or throat
• Severe dizziness
• Difficulty breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Tolvaptan

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• corticosteroids (Fluticasone, Prednisone)
• diuretics (Furosemide)