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Diclofenac, a nonsteroidal anti-inflammatory drug, carries certain risks and requires careful consideration before use. Below are important safety warnings and precautions associated with its use:

• Diclofenac may increase the risk of heart attack or stroke, with the potential for such events occurring at any time during treatment. This risk is heightened with prolonged use, particularly in older adults or individuals with existing heart disease or risk factors such as smoking, high blood pressure, diabetes, or a family history of heart disease.
• Avoid using diclofenac immediately before or after undergoing heart bypass surgery (CABG).
• There is a rare but serious risk of stomach or intestinal bleeding, which can be fatal and may occur without any warning signs. This risk is greater in older adults.
• Discontinue use and seek immediate medical attention if you experience any of the following serious side effects: persistent stomach or abdominal pain, black or bloody stools, vomit resembling coffee grounds, chest, jaw, or left arm pain, shortness of breath, unusual sweating, confusion, weakness on one side of the body, sudden changes in vision, or difficulty speaking.
• It is important to discuss the potential benefits and risks of diclofenac with your healthcare provider or pharmacist to ensure it is appropriate for your condition.

By understanding these risks and taking appropriate precautions, you can use diclofenac safely and effectively.

When taking this medication, you may experience mild side effects such as skin irritation, which can include dryness, redness, and a stinging sensation. Additionally, drowsiness or dizziness could occur. These effects are generally not serious, but if they persist or worsen, it is important to consult a healthcare professional.

Monitoring your blood pressure is advisable, as the medication may cause an increase. If you notice elevated readings, it should be addressed with a healthcare professional.

Be vigilant for more serious side effects, like signs of kidney issues such as changes in urination, or symptoms of heart failure, which might include swelling of the ankles or feet, unusual fatigue, or sudden weight gain. These require prompt medical attention.

There is a rare risk of serious liver disease associated with this drug. Seek immediate medical assistance if you experience persistent nausea or vomiting, loss of appetite, abdominal pain, yellowing of the eyes or skin, or dark urine.

Although very uncommon, severe allergic reactions can occur. Symptoms like fever, swollen lymph nodes, rash, severe dizziness, or difficulty breathing are signs to seek emergency medical help. If you encounter any other unlisted effects, reaching out to a healthcare provider is recommended.

This medication can interact with several other drugs. These include Aliskiren, ACE inhibitors like Captopril and Lisinopril, angiotensin II receptor blockers such as Losartan and Valsartan, Cidofovir, corticosteroids like Dexamethasone and Prednisone, Lithium, Methotrexate, and diuretics or "water pills" such as Furosemide. Additionally, using this medication with drugs that increase bleeding risk, like anti-platelet medications (e.g., Clopidogrel) and blood thinners (e.g., Dabigatran, Enoxaparin, Warfarin), can heighten the likelihood of bleeding.

It's important to review all your medications, including over-the-counter ones, as many contain pain relievers or fever reducers like Aspirin and NSAIDs (Ibuprofen, Ketorolac, Naproxen), which are similar to Diclofenac and may elevate side effects if used together. However, if you're on low-dose aspirin (81-162 mg daily) for heart attack or stroke prevention, continue its use unless advised otherwise by your doctor. Always consult your healthcare provider or pharmacist for personalized advice.