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When using diflorasone (Apexicon E), it is important to be aware of the following safety information to minimize potential risks and ensure effective treatment. Please read these points carefully and consult your healthcare provider if you have any questions or concerns.

• Hormonal Changes: Excessive absorption of diflorasone through the skin can lead to symptoms indicative of increased stress hormones, such as easy bruising or elevated blood sugar levels. This risk is heightened when the medication is applied to large areas of the body, used over extended periods, covered with bandages, or in younger patients.

• Skin Reactions: Users may experience skin irritation, including burning, itching, dryness, folliculitis, excessive hair growth, and changes in skin pigmentation. If you encounter any of these side effects, promptly inform your healthcare provider.

• Infection Risk: Diflorasone can reduce the skin's ability to combat infections. It is crucial to address any skin infections with suitable antifungal or antibacterial treatments while using this medication. Prolonged use increases the likelihood of infections. Discontinue use and contact your healthcare provider if you notice redness, pain, swelling, or pus at the application site.

• Eye Health Concerns: There is a potential risk for eye conditions such as cataracts and glaucoma with the use of topical steroids, including diflorasone. Although this is more common with steroid eye drops, there have been reports of eye issues in those using diflorasone for skin conditions. If you experience any vision changes, seek medical advice immediately.

For further guidance or clarification regarding your specific situation, please consult with your healthcare provider.

Common side effects:

• Burning
• Itching
• Irritation
• Dryness
• Redness at the application site

Less common but important to monitor:

• Acne
• Skin discoloration
• Excessive hair growth
• Small red bumps on the skin
• Stretch marks
• Thinning of the skin
• Rash

Serious side effects:

• Extreme tiredness
• Weight loss
• Headaches
• Swelling of the ankles or feet
• Increased thirst or urination
• Vision problems
• Severe rash
• Swelling of the face, tongue, or throat
• Dizziness
• Difficulty breathing

Diflorasone is a potent topical corticosteroid used to treat various skin conditions. While it is applied to the skin, some of the medication can be absorbed into the bloodstream, potentially leading to interactions with other medications.

One notable interaction occurs with diabetes medications, such as Glimepiride. When diflorasone is absorbed systemically, it can interfere with blood sugar control, potentially reducing the effectiveness of diabetes treatments. This risk increases when diflorasone is applied over large areas, used for extended periods, or applied to broken or inflamed skin. In such cases, it's important to monitor blood sugar levels closely and consult a healthcare provider for possible adjustments to diabetes medications.

Additionally, diflorasone may interact with other medications, including certain diuretics like Chlorthalidone and cyclopenthiazide, potentially increasing the risk of low potassium levels. It can also affect the absorption or effectiveness of drugs such as cholestyramine resin, Colesevelam, and Colestipol. Furthermore, combining diflorasone with medications like Clarithromycin, cobicistat, or Darunavir may increase the concentration of diflorasone in the bloodstream, raising the likelihood of side effects.

To minimize the risk of interactions, inform your healthcare provider about all medications, supplements, and over-the-counter products you are currently using before starting diflorasone. Avoid exceeding the recommended dose or duration of use, and do not cover treated areas with bandages or dressings unless directed by your healthcare provider, as this can increase absorption and the potential for interactions.