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The following safety information is crucial for users of this medication. Please read it carefully and discuss any questions or concerns with your healthcare provider.

• Adrenal Gland Suppression: Long-term use of hydrocortisone (Cortef) can reduce adrenal gland function, leading to decreased hormone production. Abruptly stopping or reducing the medication may cause withdrawal symptoms like fatigue, joint or muscle pain, and low energy. These risks are heightened with high doses, prolonged use, in young children, or during stress. Always consult your healthcare professional before making changes to your dosage.

• Increased Infection Risk: Prolonged or high-dose use of hydrocortisone (Cortef) can increase susceptibility to infections and mask infection symptoms. Avoid contact with individuals who have chickenpox or measles. If you have a history of tuberculosis, your healthcare provider will monitor your condition closely. Discuss vaccinations with your healthcare provider, as some may be ineffective or unsafe during treatment. Be vigilant for signs of illness and inform your healthcare provider if you feel unwell.

• Eye Health Concerns: Long-term use may increase the risk of cataracts, glaucoma, and eye infections. Do not use hydrocortisone (Cortef) if you have herpes simplex of the eye. Report any vision changes, eye pain, or blurry vision to your healthcare provider. Regular eye exams may be necessary if you are on long-term treatment.

• Behavioral Changes: Hydrocortisone (Cortef) may cause mood and behavior alterations, including depression, mood swings, anxiety, sleep disturbances, or hallucinations. Contact your healthcare provider immediately if these symptoms occur. Never adjust your dose without professional guidance.

• Bone Health Risks: Chronic use may lead to osteoporosis and fractures, and can slow growth in children. Pediatricians will monitor growth in children on long-term therapy. Discuss bone health concerns with your healthcare provider, especially if you are at risk for osteoporosis.

• Gastrointestinal Issues: Hydrocortisone (Cortef) may increase the risk of stomach damage. Avoid alcohol to prevent further irritation. Report persistent stomach pain or bloody/dark stools to your healthcare provider. Additional medication may be necessary to protect your stomach during extended use.

• Cardiovascular and Renal Effects: This medication can cause high blood pressure, fluid retention, and affect kidney function, potentially worsening heart failure or kidney issues. Consult your healthcare provider if you have a history of these conditions to ensure safe use.

• Contraindications: Do not use this medication if you have a systemic fungal infection. Consult your healthcare provider if this condition applies to you.

In case of overdose, seek immediate medical assistance. Always adhere to prescribed dosages and guidelines to minimize risks.

When taking this medication, you may experience some common side effects such as nausea, heartburn, headache, insomnia, increased sweating, and acne. These are generally mild and should not cause alarm, but if they persist or worsen, it is advisable to consult with your healthcare provider. Additionally, some individuals may notice changes in mood, weight gain, increased appetite, or experience high blood pressure and muscle weakness.

It is important to be aware that this medication can affect your immune system, potentially making you more susceptible to infections. If you experience symptoms like fever, chills, a persistent cough, or difficulty with wound healing, it is crucial to seek medical advice promptly. Prolonged use may also lead to oral thrush or yeast infections, so watch for symptoms such as white patches in the mouth or changes in vaginal discharge.

In rare cases, this medication may elevate blood sugar levels, potentially triggering or worsening diabetes. Symptoms like increased thirst or urination should be reported to your healthcare provider, especially if you have diabetes, as adjustments to your treatment plan may be necessary.

Serious side effects, although uncommon, require immediate medical attention. These include unusual fatigue, swelling in the ankles or feet, vision problems, easy bruising or bleeding, mood changes, muscle pain, thinning skin, delayed wound healing, menstrual changes, bone pain, or signs of internal bleeding like stomach pain or black stools. Allergic reactions are rare but can be severe, presenting symptoms such as rash, swelling, severe dizziness, or breathing difficulties. If you experience any severe side effects, contact your healthcare provider immediately. Always stay informed and proactive about your health while using this medication.