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This document outlines crucial safety and warning information related to the use of dronabinol (Marinol). Please review this guidance thoroughly and discuss any concerns with your healthcare provider.

• Mental Health Considerations: Individuals with mental health conditions such as mania, depression, or schizophrenia may experience exacerbated symptoms when using dronabinol (Marinol). Inform your healthcare provider of all your medical conditions before starting this medication. Be aware that it can cause dizziness, drowsiness, and impair concentration. Refrain from driving, operating heavy machinery, or engaging in activities requiring focus until you understand how dronabinol affects you. This risk is heightened in older adults, those with a history of mental health issues, individuals taking other sedative medications, and those consuming alcohol.

• Seizure Risk: Dronabinol may increase seizure risk. If you have a history of seizures, consult your healthcare provider to determine if this medication is suitable for you. Should a seizure occur, discontinue use and contact your healthcare provider immediately.

• Cardiovascular Effects: This medication can alter blood pressure, increase heart rate, and cause faintness. Those with a history of heart problems or those taking medications that affect heart rate or blood pressure should exercise caution. Discuss any such conditions with your provider before starting dronabinol.

• Potential for Misuse: Dronabinol is a schedule III controlled substance due to its potential for misuse and dependence. Misuse involves using the medication for non-medical purposes to achieve euphoria, while dependence may develop with long-term use, leading to withdrawal symptoms if discontinued abruptly. Your healthcare provider will manage your dosage and taper it gradually if necessary. This risk is higher for individuals with a history of substance or alcohol misuse.

• Gastrointestinal Issues: In rare cases, dronabinol may worsen nausea, vomiting, or stomach pain. Notify your healthcare provider if your symptoms do not improve or worsen. Dosage adjustments or discontinuation may be required.

• Contraindications: Avoid using this medication if you are allergic to sesame oil. Always consult your healthcare provider if you have any concerns regarding contraindications.

This information is intended to ensure safe and effective use of dronabinol (Marinol). If you have any questions or require further clarification, please reach out to your healthcare provider.

Common side effects:

• Dizziness
• Euphoria
• Sleepiness
• Nausea
• Vomiting
• Stomach pain
• Lightheadedness

Less common but important to monitor:

• Confusion
• Coordination problems
• Slurred speech
• Anxiety
• Nervousness
• Fast heartbeat
• Flushing
• Hallucinations
• Memory loss
• Lack of energy

Serious side effects:

• Seizures
• Worsening mental symptoms (depression, mania, or schizophrenia)
• Changes in blood pressure
• Allergic reactions (rash, itching or swelling, severe dizziness, trouble breathing)

Interactions with high risk of serious adverse effects and should be avoided:

• Disulfiram
• Metronidazole

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Codeine
• Hydrocodone
• Alcohol
• Marijuana
• Alprazolam
• Lorazepam
• Zolpidem
• Carisoprodol
• Cyclobenzaprine
• Cetirizine
• Diphenhydramine